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Local excision carcinoma in early stage

机译：早期局部切除癌

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AIM: To assess the validity of local excision for the early stage low rectal cancer as an effective treatment alternative to radical resection. METHODS: A retrospective medical chart review was done in 47 patients with early stage low rectal carcinoma who underwent local excision from November 1980 through November 1999 at Cancer Hospital of Chinese Academy of Medical Sciences (CAMS). The patients were treated by either transanal (40 cases), trans-sacral (5 cases), or trans-vaginal (2 cases) excision of tumors and no death was related to surgery. Sixteen patients received postoperative radiotherapy. RESULTS: T1 and T2 lesion was found in 36 (76.6 %) and 11 patients (23.4 %) respectively. The overall local tumor recurrence rate was 14.9 % (7/47), with an average recurrence time of 21 months. Among these 7 recurrent patients, there were 4 T1 and 3 T2 lesions. Microscopically the surgical incisal margin was negative in 45 (95.7 %) and positive in 2 patients (4.3 %); Both of the later had developed local recurrence. The overall 5-year survival rate was 91.7 %, in which there were 94.4 % for T1 and 83.3 % for T2 tumors. T stage, intravessel tumor thrombosis, lymphocytic infiltration and histological grade were not found to be significant by related to the local recurrence and survival CONCLUSION: Local tumor excision was a safe procedure for the treatment of early stage low rectal carcinoma with minimal morbidity and mortality, which might serves as one of the primary surgical treatment methods for the disease of this kind.
机译：目的：评估局部切除对于早期低位直肠癌作为根治性切除术的有效治疗方法的有效性。方法：回顾性分析1980年11月至1999年11月在中国医学科学院肿瘤医院（CAMS）接受局部切除的47例早期低位直肠癌患者的病历。通过经肛门（40例），经ac（5例）或经阴道（2例）的肿瘤切除治疗，无死亡与手术相关。十六名患者接受了术后放疗。结果：分别在36例（76.6％）和11例（23.4％）患者中发现了T1和T2病变。总体局部肿瘤复发率为14.9％（7/47），平均复发时间为21个月。在这7例复发患者中，有4个T1和3个T2病变。在显微镜下，手术切缘的阴性为45例（95.7％），阳性为2例（4.3％）；后来两者都发展出局部复发。总体5年生存率为91.7％，其中T1肿瘤为94.4％，T2肿瘤为83.3％。与局部复发和生存相关，T期，血管内肿瘤血栓形成，淋巴细胞浸润和组织学分级均无统计学意义。结论：局部肿瘤切除术是治疗早期低位直肠癌的一种安全方法，其发病率和死亡率均最低，这可能是这类疾病的主要外科治疗方法之一。

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