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首页> 外文期刊>Bangladesh Journal of Medical Science >Lycopene - tomato's secret weapon against oxidative stress
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Lycopene - tomato's secret weapon against oxidative stress

机译：番茄红素-番茄抗氧化应激的秘密武器

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Back ground: Lycopene, 40 carbon acyclic carotenoid containing 11 conjugated double bonds, is a phytochemical found in tomatoes and other red fruits. Oxygen derived free radicals are the most reactive species and as an antioxidant lycopene has a singlet oxygen quenching ability twice as high as that of ?-carotene and 10 times higher that of ?-tocoferol, lycopene participate in a host of chemical reactions to protect critical cellular biomolecules including lipid, proteins and DNA. Materials and Methods: The present study include 30 subjects having oxidative stress, age between 40-60 years, nonsmoker, with no history of chronic systemic illness and no medication were taken as patients.30 patients matched healthy subjects were taken as control. All subjects were selected from outpatient department of NSCB Medical College Jabalpur M.P. After estimation of base line antioxidant enzyme and vitamins, we supplement 180 gm of tomato (products like soup, paste. ketchup) contain 12 mg of lycopene to the patient group. After 60 days of lycopene supplementation oxidative stress biomarkers like SOD, GPX, GR, GSH, lipid peroxidation product MDA and other antioxidant vitamins A, vitamin C, vitamin E were estimated in patient's blood sample. Results: The main result of the study revealed that lipid per oxidation product MDA was found to be decreased significantly but after lycopene supplementation levels were improved. The results of SOD , GPX, GR, GSH,Vitamin A ,Vitamin E and Vitamin C were significantly increased after lycopene supplementation, it indicates the improved antioxidant profile after the supplementation of lycopene. Conclusion: There was a significant decrease in oxidative stress after the supplementation of lycopene therefore the study suggest that body's internal production of antioxidant is not enough to neutralize all free radicals, so increased dietary intake of antioxidant lycopene in the form of tomato products is beneficial, which is easily available in developing country like India.
机译：背景：番茄红素是一种含有11个共轭双键的40碳无环类胡萝卜素，是一种在番茄和其他红色水果中发现的植物化学物质。氧衍生的自由基是反应性最高的物质，由于抗氧化剂番茄红素具有单线态氧猝灭能力，是α-胡萝卜素的两倍，是α-生育酚的十倍，所以番茄红素参与许多化学反应以保护关键分子。细胞生物分子，包括脂质，蛋白质和DNA。材料与方法：本研究纳入30例氧化应激，年龄在40-60岁之间，不吸烟，无慢性全身疾病史且无药物治疗的受试者作为患者。以30例与健康受试者匹配的患者作为对照组。所有受试者均选自NSCB医学院Jabalpur M.P.在估算了基线抗氧化酶和维生素后，我们向患者组补充了180克番茄（汤，糊，番茄酱等产品）中含有12毫克番茄红素。补充番茄红素60天后，在患者的血液样本中评估了氧化应激生物标志物，如SOD，GPX，GR，GSH，脂质过氧化产物MDA和其他抗氧化剂维生素A，维生素C，维生素E。结果：研究的主要结果表明，发现每氧化产物MDA的脂质显着降低，但番茄红素的补充水平有所提高。番茄红素添加后，SOD，GPX，GR，GSH，维生素A，维生素E和维生素C的含量均显着增加，表明番茄红素添加后抗氧化性得到改善。结论：补充番茄红素后，氧化应激显着降低，因此研究表明，人体内部产生的抗氧化剂不足以中和所有自由基，因此增加番茄制品形式的抗氧化剂番茄红素的饮食摄入量是有益的，在印度等发展中国家很容易获得。

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