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Chemotherapy and Dietary Phytochemical Agents

机译：化学疗法和饮食植物化学制剂

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Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way.
机译：通过靶向肿瘤细胞的增殖潜能和转移能力，化学疗法已经用于癌症治疗近70年。尽管有效的化疗药物的开发取得了进展，但是它们对正常组织的毒性和在多器官系统中的不良副作用以及耐药性仍然是成功临床使用的主要障碍。细胞毒性剂会大大降低癌症患者的生活质量，表现为急性不适，并且在治疗后的数年内都会影响幸存者的生活。毒性通常限制了抗癌药的有效性，也是许多患者中止治疗的原因。营养方法可能是帮助将癌症治疗提高到新的成功水平的方法，因为用天然植物化学物质补充或支持人体不仅可以减少不良副作用，而且还可以提高化学治疗的有效性。各种植物来源的化合物提高了细胞毒剂的效率，降低了其抗药性，降低并减轻了毒副作用，降低了肿瘤溶解综合征的风险，并为化学疗法的身体排毒。因此，使用各种植物化学物质的个性化方法为标准癌症治疗提供了新的维度，从而以复杂而互补的方式改善了治疗效果。

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