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首页> 外文期刊>Advanced Biomedical Research >Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker
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Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker

机译：偏头痛患者血液中前列腺素I2（prostacyclin）受体的表达：潜在的生物标志物

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Background: Migraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group. Materials and Methods: Extracted mRNA from lymphocytes of 50 cases and 50 controls was used to synthesize cDNA. Real-time polymerase chain reaction was performed, and the data were analyzed. Our results show that PTGIR mRNA expression in cases was significantly higher than the control group ( P = 0.010). Results: In conclusion, mRNA expression of PTGIR in the blood of people with migraines could be considered as a biomarker. Conclusion: In addition, repression of PTGIR gene expression by methods such as using siRNA is probably suitable for therapy of migraine patients.
机译：背景：偏头痛是最常见的慢性神经系统疾病，可能与血管舒张有关。根据偏头痛中前列腺素I2（prostacyclin）受体（PTGIR）在血管舒张中的作用，我们决定与合适的对照组研究偏头痛患者中PTGIR表达的变化。材料与方法：从50例淋巴细胞和50例对照中提取的mRNA用于合成cDNA。进行实时聚合酶链反应，并分析数据。我们的结果表明，病例中PTGIR mRNA的表达显着高于对照组（P = 0.010）。结果：总之，偏头痛患者血液中PTGIR的mRNA表达可被视为生物标志物。结论：此外，通过使用siRNA等方法抑制PTGIR基因表达可能适用于偏头痛患者。

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