• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Biotechnology >Structural changes and effect of denopamine on alveolar fluid clearance in hypoxic rat lungs
【24h】

Structural changes and effect of denopamine on alveolar fluid clearance in hypoxic rat lungs

机译：尼多巴胺的结构变化及对缺氧大鼠肺泡液清除的影响

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Terbutaline?(β2-adrenergic agonist)?can increase alveolar fluid clearance (AFC) under physiologic and pathologic conditions. It is unknown whether β1-adrenergic agonists also increase AFC under pathologic conditions. The aim of this study was to investigate the effect of denopamine (β1- adrenergic agonist ) on AFC in hypoxic lung injury and the possible mechanisms involved. Hypoxic rats were exposed to 10% oxygen. 10-5?mol/L denopamine alone or combined with β receptor antagonists, Na+?channel blocker, or Na+/K+-ATPase blocker were perfused into the alveolar space of rats exposed to 10% oxygen for 48 h. AFC and total lung water content (TLW) were measured. AFC did not change for the first 24 h but then decreased after 48h exposure to 10% oxygen. The perfusion of denopamine significantly increased AFC in normoxic and hypoxic rats. The AFC- stimulating effect of denopamine lowered with amiloride (a Na+?channel blocker) and ouabain (a Na+/K+-ATPase inhibitor) by 35 and 53%, respectively. Colchicine significantly inhibited the effect of denopamine. Denopamine can increase the AFC during hypoxic lung injury in rats and accelerate the absorption of pulmonary edema.
机译：在生理和病理条件下，特布他林（β2-肾上腺素能激动剂）可以增加肺泡液清除率（AFC）。尚不清楚在病理情况下β1-肾上腺素能激动剂是否也会增加AFC。这项研究的目的是研究在低氧性肺损伤中denopamine（β1-肾上腺素能激动剂）对AFC的作用及其可能的机制。缺氧大鼠暴露于10％的氧气。将单独或与β受体拮抗剂，Na +β通道阻滞剂或Na + / K + -ATPase阻滞剂组合使用的10-5？mol / L地那巴胺灌注到暴露于10％氧气的大鼠肺泡腔中48小时。测量了AFC和总肺水含量（TLW）。 AFC在最初的24小时内没有变化，但是在暴露于10％的氧气中48小时后降低了。在常氧和低氧大鼠中，去甲多巴胺的灌注显着增加AFC。阿米洛利（一种Na +通道阻滞剂）和哇巴因（一种Na + / K + -ATPase抑制剂）分别降低了多巴胺的AFC刺激效果35％和53％。秋水仙碱显着抑制了多巴胺的作用。地那巴胺可以在缺氧性肺损伤大鼠中增加AFC并加速肺水肿的吸收。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号