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Toward MRI‐based whole‐brain health assessment: The brain atrophy and lesion index (BALI)

机译：进行基于MRI的全脑健康评估：脑萎缩和病变指数（BALI）

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There have been many attempts to assess the elements of age‐ and dementia‐ related neurodegenerative changes in the brain using MRI; however, traditionally assessments focus only on single deficit. Over the past few years, our group has worked to create and validate the Brain Atrophy and Lesion Index (BALI) as an MRI‐based whole‐brain structural degeneration rating scale. The BALI can be used for applications in aging and dementia across the entire brain and can be applied to common clinical MR images. As a whole‐brain structural health assessment, the BALI gives a more representative picture of how the brain ages. During the aging process, multiple elements of degeneration accumulate and interact to overwhelm repair processes and cause high‐level failure in the function of the brain. To reflect this process, the BALI combines the assessment of several neurodegeneration changes into one scale. The BALI evaluation can be performed quickly and has been validated for use by non‐neuroradiology expert raters trained with the method. This review gives a brief overview of the content of the BALI; covers the development, refinement, and application of the method; and provides insights about future development and clinical implementation of MRI‐based whole‐brain health assessment in aging and dementia.
机译：已经进行了许多尝试使用MRI来评估大脑中与年龄和痴呆相关的神经退行性变化的元素。但是，传统上，评估只关注单一赤字。在过去的几年中，我们的小组一直致力于创建和验证脑萎缩和病变指数（BALI），作为基于MRI的全脑结构退化等级量表。 BALI可用于整个大脑的衰老和痴呆，并可应用于常见的临床MR图像。作为全脑结构健康评估，BALI可以更清楚地说明大脑的年龄。在衰老过程中，多种变性元素积聚并相互作用，使修复过程不堪重负，并导致大脑功能的高度衰竭。为了反映这一过程，BALI将几种神经退行性变化的评估合并为一个量表。 BALI评估可以快速执行，并且已通过该方法培训的非神经放射学专家评估人员进行了验证。这篇评论简要介绍了BALI的内容;涵盖了该方法的开发，完善和应用;并提供有关在衰老和痴呆症中基于MRI的全脑健康评估的未来发展和临床实施的见解。

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