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首页> 外文期刊>Advancements in Life Sciences >Impact of IL28B gene variants (rs12979860) in peg-IFN therapy against Chronic Hepatitis B Pakistani patients
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Impact of IL28B gene variants (rs12979860) in peg-IFN therapy against Chronic Hepatitis B Pakistani patients

机译：IL28B基因变异（rs12979860）在peg-IFN治疗中对巴基斯坦慢性乙型肝炎患者的影响

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Background: Genome wide association studies elucidate that IL28B rs12979860 genetic polymorphism has a substantial role as a pretreatment predictor during PEG-IFN therapy in Hepatitis C virus (HCV) infection, however its role in chronic hepatitis B (CHB) is ambiguous. Methods: In this study, we have investigated the role of IL28B variant rs12979860 for chronic hepatitis B (CHB) infection. 200 CHB patients were treated for 24 weeks, then we carried out our study on these patients. Moreover, all patients were investigated for IL28B rs12979860 genotypes CC, CT, TT through RT-PCR. Based on our preliminary results we categorized these patients into two groups i.e. Responder ￠R (n = 104) and Non-responder￠NR (n = 96). Results: The proportion of IL28B CC, CT, TT genotypes were in both responder and non-responder groups as (72.1%, 25.0%, 2.9% vs 53.1%, 40.6%, 6.2% respectively; P = 0.02). In this study CC was the most frequent genotype, which has significant outcome in PEG-IFN therapy in both R and NR groups (72.1% vs 53.1%) (P = 0.03), while CT and TT were found as (25.0% vs 40.6%) (P = 0.1, 2.09% vs 6.2%) (P = 0.3) respectively. Conclusion: Current study clearly demonstrates that IL28B rs12979860 polymorphism is a pretreatment predictor during PEG-IFN therapy in CHB infection, and patients with favorable genotype of rs12979860 (CC) may clear the virus than the non-favorable genotypes (CT, TT) in Pakistani population.
机译：背景：全基因组关联研究阐明，IL28B rs12979860遗传多态性在丙型肝炎病毒（HCV）感染的PEG-IFN治疗期间作为预处理的预测因子具有重要作用，但在慢性乙型肝炎（CHB）中的作用尚不清楚。方法：在这项研究中，我们研究了IL28B变体rs12979860在慢性乙型肝炎（CHB）感染中的作用。 200名CHB患者接受了24周的治疗，然后我们对这些患者进行了研究。此外，通过RT-PCR对所有患者的IL28B rs12979860基因型CC，CT，TT进行了调查。根据我们的初步结果，我们将这些患者分为两组，即响应者￠ R（n = 104）和无反应者￠ NR（n = 96）。结果：IL28B CC，CT，TT基因型在应答者和非应答者组中的比例分别为（分别为72.1％，25.0％，2.9％和53.1％，40.6％，6.2％; P = 0.02）。在这项研究中，CC是最常见的基因型，在R和NR组中PEG-IFN治疗均具有显着结果（72.1％vs 53.1％）（P = 0.03），而CT和TT分别为（25.0％vs 40.6）。 ％）（P = 0.1、2.09％和6.2％）（P = 0.3）。结论：目前的研究清楚地表明，IL28B rs12979860基因多态性是CHB感染PEG-IFN治疗期间的预处理预测指标，并且具有良好基因型rs12979860（CC）的患者清除病毒的可能性要高于巴基斯坦的不良基因型（CT，TT）。人口。

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