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首页> 外文期刊>International Journal of Environmental Research and Public Health >Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure
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Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure

机译：世界贸易中心粉尘暴露对社区成员结节病的临床评价

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Background : Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods : Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results : Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions : WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.
机译：背景：结节病是一种肉芽肿性疾病，涉及胸内和胸外器官。遗传和环境因素，例如9/11之后接触世界贸易中心（WTC）的粉尘，可能在临床表现中起作用。暴露于WTC尘土中社区成员结节病的特征可以进一步了解环境暴露与结节病之间的关系。方法：在WTC环境卫生中心（EHC）中鉴定出有结节病的患者，这是一项针对社区成员的治疗计划。人口统计学和临床​​数据来自标准化的问卷调查表和图表审查。用标准仪器评估器官受累情况。结果：在WTC EHC中，在9/11之后，有87例结节病。与非结节病WTC EHC患者相比，结节病病例更可能是非洲裔美国人，当地工人，并且有更多的呼吸道症状。许多（46％）的胸部影像学检查具有≥Scadding第三阶段，并且肺功能指标降低。在33/87（38％）的人群中发现胸外受累，累及的器官多种多样。结论：社区成员中暴露于WTC的结节病通常以严重的肺部疾病和多种胸外累及为特征。需要进一步分析以表征疾病进展或解决的过程。

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