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首页> 外文期刊>International Journal of General Medicine >Cognition and dual-task performance in older adults with Parkinson's and Alzheimer's disease
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Cognition and dual-task performance in older adults with Parkinson's and Alzheimer's disease

机译：帕金森氏症和阿尔茨海默氏病患者的认知和双任务表现

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Background: Patients with neurodegenerative diseases usually experience significant functional deficits. Older adults with Parkinson's disease (PD) and Alzheimer's disease (AD) may suffer from both motor and cognitive impairments, making them especially vulnerable to poor dual-task performance. Objective: To analyze the dual-task cost of walking in subjects with PD and AD exposed to motor and cognitive distracters. Methods: A cross-sectional study was conducted involving 126 older adults comprising three groups: PD (n=43), AD (n=38), and control (n=45). The subjects were evaluated using the Timed Up and Go (TUG) test administered with motor and cognitive distracters. Mixed-design analysis of variance (ANOVA) with cognition as a covariant factor was used to test the possible main effects of dual-task on motion. A 5% threshold for significance was set, with a 95% confidence interval (CI). The partial eta square (n2p) analysis was included to estimate the magnitude of effect. Results: Examining the effects for dual-task, ANOVA revealed the main effect for group×task interactions (F=13.09; P=0.001; n2p =0.178), for task (F=8.186; P=0.001; n2p =0.063) but not for group (F=2.954; P=0.056; n2p =0.047). Cognition applied as a covariant factor indicated interference on dual-tasks (F=30.43; P=0.001; n2p =0.201). Conclusion: The findings of this study suggest that dual-task interference is a particularly noticeable problem in PD and AD, affecting subjects' ability to appropriately adapt to environmental challenges.
机译：背景：患有神经退行性疾病的患者通常会出现明显的功能缺陷。患有帕金森氏病（PD）和阿尔茨海默氏病（AD）的老年人可能同时患有运动和认知功能障碍，这使他们特别容易遭受不良的双重任务表现。目的：分析在患有运动和认知干扰的PD和AD患者中行走的双重任务成本。方法：进行了一项横断面研究，涉及126位老年人，分为三组：PD（n = 43），AD（n = 38）和对照组（n = 45）。使用与运动和认知干扰物一起进行的定时走（TUG）测试对受试者进行评估。以认知为协变量的方差混合设计分析（ANOVA）用于测试双任务对运动的可能主要影响。设置的重要度阈值为5％，置信区间（CI）为95％。包括部分eta方（n2p）分析以估计影响的大小。结果：检查双重任务的影响，方差分析揭示了组×任务交互的主要影响（F = 13.09; P = 0.001; n2p = 0.178），对于任务（F = 8.186; P = 0.001; n2p = 0.063），但不适用于组（F = 2.954; P = 0.056; n2p = 0.047）。应用为协变量的认知表明对双重任务的干预（F = 30.43; P = 0.001; n2p = 0.201）。结论：这项研究的结果表明，双任务干扰是PD和AD中一个特别明显的问题，影响受试者适应环境挑战的能力。

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