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首页> 外文期刊>Endocrine journal >Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients
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Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

机译：L-甲状腺素替代对明显和亚临床甲状腺功能减退患者的载脂蛋白B-48的影响

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References(37) Cited-By(3) Apolipoprotein B-48 (ApoB-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis. We evaluated the effect of L-thyroxine (L-T4) replacement on serum ApoB-48 levels in patients with primary hypothyroidism. Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study. The lipid profiles, including ApoB-48, were measured in patients with hypothyroidism before and 3 months after L-T4 replacement. After L-T4 replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein(a) (Lp(a)), were significantly decreased in patients with OH. In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (ApoB), and ApoB-48 decreased significantly after L-T4 replacement. The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA-1), and Lp(a) did not change significantly. In all 36 patients, the reduction in the ApoB-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P4 replacement might reduce serum levels of ApoB-48 in both OH and SH patients. Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism.
机译：参考文献（37）被引用的By（3）载脂蛋白B-48（ApoB-48）是乳糜微粒和乳糜微粒残留的成分，被认为是动脉粥样硬化的危险因素之一。我们评估了L-甲状腺素（L-T4）替代对原发性甲状腺功能减退患者血清ApoB-48水平的影响。共有18例明显的甲状腺功能减退（OH）患者和18例亚临床甲状腺功能减退（SH）患者参加了该研究。在更换L-T4之前和之后3个月对甲状腺功能低下的患者进行了包括ApoB-48在内的血脂测定。更换L-T4后，OH患者的所有脂蛋白（不包括脂蛋白（a）（Lp（a）））的血清浓度均显着降低。在具有SH的专利中，血清总胆固醇（TC），非高密度脂蛋白胆固醇（non-HDL-C），残留样颗粒胆固醇（RLP-C），载脂蛋白B（ApoB）和ApoB- L-T4更换后48明显下降。血清甘油三酸酯（TG），HDL-C，低密度脂蛋白胆固醇（LDL-C），载脂蛋白A1（ApoA-1）和Lp（a）的水平无明显变化。在所有36例患者中，ApoB-48水平的降低与TSH水平的降低显着相关（r = 0.39，P4替代治疗可能会降低OH和SH患者的ApoB-48血清水平。 OH和SH患者中48可能与甲状腺功能减退患者乳糜微粒残留的代谢紊乱有关。

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