...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endocrine journal >Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients
【24h】

Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

机译：L-甲状腺素替代对明显和亚临床甲状腺功能减退患者的载脂蛋白B-48的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apolipoprotein B-48 (ApoB-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis. We evaluated the effect of L-thyroxine (L-T_4) replacement on serum ApoB-48 levels in patients with primary hypothyroidism. Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study. The lipid profiles, including ApoB-48, were measured in patients with hypothyroidism before and 3 months after L-T_4 replacement. After L-T_4 replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein(a) (Lp(a)), were significantly decreased in patients with OH. In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (ApoB), and ApoB-48 decreased significantly after L-T4 replacement. The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA-1), and Lp(a) did not change significantly. In all 36 patients, the reduction in the ApoB-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P<0.05). This study showed clearly that L-T_4 replacement might reduce serum levels of ApoB-48 in both OH and SH patients. Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism.
机译：载脂蛋白B-48（ApoB-48）是乳糜微粒和乳糜微粒残留的成分，被认为是动脉粥样硬化的危险因素之一。我们评估了L-甲状腺素（L-T_4）替代对原发性甲状腺功能减退患者血清ApoB-48水平的影响。共有18例明显的甲状腺功能减退（OH）患者和18例亚临床甲状腺功能减退（SH）患者参加了该研究。在更换L-T_4之前和之后3个月对甲状腺功能低下的患者进行了包括ApoB-48在内的血脂测定。更换L-T_4后，OH患者的所有脂蛋白（不包括脂蛋白（a）（Lp（a）））的血清浓度均显着降低。在具有SH的专利中，血清总胆固醇（TC），非高密度脂蛋白胆固醇（non-HDL-C），残留样颗粒胆固醇（RLP-C），载脂蛋白B（ApoB）和ApoB- L-T4更换后48明显下降。血清甘油三酸酯（TG），HDL-C，低密度脂蛋白胆固醇（LDL-C），载脂蛋白A1（ApoA-1）和Lp（a）的水平无明显变化。在所有36例患者中，ApoB-48水平的降低与TSH水平的降低显着相关（r = 0.39，P <0.05）。这项研究清楚地表明，在OH和SH患者中，L-T_4替代可能会降低ApoB-48的血清水平。 OH和SH患者血清ApoB-48的这种变化可能与甲状腺功能减退患者乳糜微粒残留的代谢紊乱有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号