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首页> 外文期刊>Romanian Journal of Biophysics >OXIDATIVE STRESS IN DIABETES MELLITUS
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OXIDATIVE STRESS IN DIABETES MELLITUS

机译：糖尿病患者的氧化应激

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Our aim was to evaluate oxidative stress in diabetes mellitus by the measurement of biophysical parameters (changes) of hemoglobin macromolecule and some biochemical parameters on two groups of diabetic patients, non-insulin dependent diabetes mellitus (NIDDM), and insulin-dependent diabetes mellitus (IDDM). This study has been conducted on 45 NIDDM, 30 IDDM, compared to 20 healthy subjects. Blood glucose, glycosylated hemoglobin (HbA1c), fructosamine, plasma insulin, plasma malondialdehyde (MDA), erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-Red) were measured. Also the biophysical parameters, electrical conductivity of hemoglobin, auto-oxidation rate of hemoglobin, and hemoglobin derivatives were measured. Diabetic patients (NIDDM, IDDM) have significant increases in blood glucose, glycosylated (HbA1c), fructosamine with a concomitant signifant decrease in Plasma insulin compared to control. Diabetic patients (NIDDM, IDDM) have a significant high level of MDA compared to control. Diabetic patients (NIDDM, IDDM) have a significant increase in SOD activity, and a significant decrease of GSH compared to control. Significant increases in electrical conductivity of Hb, hemoglobin auto-oxidation rate and hemoglobin derivatives in diabetic patient compared to control. IDDM have a higher level of hemoglobin auto-oxidation rate when compared to NIDDM. Diabetic patients undergo an important oxidative stress that is low in NIDDM compared to IDDM, suggesting metabolic differences between the two types of diabetes. Met-Hb is an important indicator for oxidative stress in diabetes.
机译：我们的目的是通过测量两组糖尿病患者非胰岛素依赖型糖尿病（NIDDM）和胰岛素依赖型糖尿病的血红蛋白大分子的生物物理参数（变化）和一些生化参数来评估糖尿病的氧化应激（ IDDM）。这项研究针对45位NIDDM，30位IDDM进行，而20位健康受试者则进行了这项研究。血糖，糖基化血红蛋白（HbA1c），果糖胺，血浆胰岛素，血浆丙二醛（MDA），红细胞还原型谷胱甘肽（GSH），超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GSH-Red）是测量。还测量了生物物理参数，血红蛋白的电导率，血红蛋白的自氧化率和血红蛋白衍生物。与对照组相比，糖尿病患者（NIDDM，IDDM）的血糖，糖基化（HbA1c），果糖胺的血糖显着增加，血浆胰岛素显着下降。与对照组相比，糖尿病患者（NIDDM，IDDM）的MDA水平明显较高。与对照组相比，糖尿病患者（NIDDM，IDDM）的SOD活性显着增加，GSH显着降低。与对照组相比，糖尿病患者的血红蛋白电导率，血红蛋白自氧化率和血红蛋白衍生物显着增加。与NIDDM相比，IDDM的血红蛋白自氧化率更高。与IDDM相比，糖尿病患者的NIDDM氧化应激低，这表明两种糖尿病之间的代谢差异。 Met-Hb是糖尿病氧化应激的重要指标。

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