Synthesis and Evaluation of New 2-Iminothiazolidin-4-one and Thiazolidin-2,4-dione Derivatives as Antimicrobial and Anti-inflammatory Agents

Bayoumi Waleed A.; Abdel-Rhman Shaymaa H.; Shaker Mohamed E.

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Synthesis and Evaluation of New 2-Iminothiazolidin-4-one and Thiazolidin-2,4-dione Derivatives as Antimicrobial and Anti-inflammatory Agents

机译：新型2-Iminothiazolidin-4-one和Thiazolidin-2,4-dione衍生物作为抗菌和消炎药的合成和评价

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A new series of 2-iminothiazolidin-4-ones and thiazolidin-2,4-diones were designed and synthesized. The targetcompounds were evaluated for antimicrobial and anti-inflammatory activities, aiming to find a candidate carrying dualactivities. The antibacterial activity was determined by cup-diffusion technique and NCCLS broth dilution method. TheMICs were determined using 96-well microtitre plates, while the anti-inflammatory activity was determined using carrageenan-induced rat paw edema model. The results revealed that target compounds showed no antifungal activity towardstested Fungi, whereas the antibacterial activity was mainly on Gram-positive bacteria. The anti-inflammatory activitywas observed in compounds belonging to the thiazolidin-2,4-dione series. The structures of the newly synthesizedcompounds were confirmed by physical and spectral data.

机译：设计并合成了一系列新的2-iminothiazolidin-4-ones和thiazolidin-2,4-diones。对目标化合物的抗微生物和抗炎活性进行了评估，旨在寻找具有双重活性的候选药物。通过杯扩散技术和NCCLS肉汤稀释法测定其抗菌活性。使用96孔微量滴定板测定MIC，而使用角叉菜胶诱导的大鼠爪水肿模型测定抗炎活性。结果表明，目标化合物对经测试的真菌没有抗真菌活性，而抗菌活性主要针对革兰氏阳性细菌。在属于噻唑烷二-2，4-二酮系列的化合物中观察到了抗炎活性。通过物理和光谱数据证实了新合成的化合物的结构。

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《Open Chemistry Journal》 |2014年第1期|共6页
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Bayoumi Waleed A.; Abdel-Rhman Shaymaa H.; Shaker Mohamed E.;
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Synthesis and Evaluation of New 2-Iminothiazolidin-4-one and Thiazolidin-2,4-dione Derivatives as Antimicrobial and Anti-inflammatory Agents

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