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首页> 外文期刊>Sao Paulo Medical Journal >Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure
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Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

机译：心力衰竭患者腰围增大并伴甘油三酸酯升高（高甘油三酸酯腰部表型）和HDL胆固醇

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CONTEXT AND OBJECTIVE: The association of serum triglycerides plus waist circumference seems to be a good marker of cardiovascular risk and has been named the a??hypertriglyceridemic waista?? phenotype. The aim of our study was to investigate the association between the hypertriglyceridemic waist phenotype and HDL-cholesterol among patients with heart failure. DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in southern Brazil. METHODS: We included patients with heart failure aged > 40 years. Anthropometric assessment (weight, height, waist and hip circumferences) was performed; body mass index (BMI) and waist-hip ratio were calculated and lipid measurements (serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were collected. In men and women, respectively, waist circumference a?￥ 94 cm and a?￥ 80 cm, and triglycerides a?￥ 150 mg/dl were considered abnormal and were used to identify the hypertriglyceridemic waist phenotype. Analyses of covariance were used to evaluate possible associations between levels of HDL-cholesterol and the hypertriglyceridemic waist phenotype, according to sex. RESULTS: 112 participants were included, of whom 62.5% were men. The mean age was 61.8 ?± 12.3 years and the mean ejection fraction was 40.1 ?± 14.7%. Men and woman presented mean HDL-cholesterol of 40.5 ?± 14.6 and 40.9 ?± 12.7 mg/dl, respectively. The prevalence of the hypertriglyceridemic waist phenotype was 25%. There was a significant difference in mean HDL-cholesterol between men with and without the hypertriglyceridemic waist phenotype (32.8 ?± 14.2 versus 42.1 ?± 13.7 mg/dl respectively; P = 0.04), even after adjustment for age, body mass index, type 2 diabetes mellitus, use of statins and heart failure etiology. CONCLUSIONS: The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.
机译：语境和目的：血清甘油三酸酯与腰围的关联似乎是心血管疾病风险的良好标志，被称为“高甘油三酯血症腰围”。表型。我们研究的目的是研究心力衰竭患者中高甘油三酯血症腰部表型与HDL-胆固醇之间的关系。设计与环境：在巴西南部一家三级医院进行的横断面研究。方法：我们纳入了≥40岁的心力衰竭患者。进行人体测量评估（体重，身高，腰围和臀围）;计算体重指数（BMI）和腰臀比，并收集脂质测量值（血清总胆固醇，LDL-胆固醇，HDL-胆固醇和甘油三酸酯）。在男性和女性中，腰围a？￥ 94 cm和a？￥ 80 cm和甘油三酸酯a？￥ 150 mg / dl被认为是异常的，并用于识别高甘油三酸酯血症的腰部表型。根据性别，协方差分析用于评估HDL-胆固醇水平与高甘油三酯血症腰部表型之间的可能关联。结果：包括112名参与者，其中62.5％是男性。平均年龄为61.8±12.3岁，平均射血分数为40.1±14.7％。男性和女性的平均HDL胆固醇分别为40.5±14.6和40.9±12.7 mg / dl。高甘油三酯血症腰部表型的患病率为25％。即使调整了年龄，体重指数，类型，在有和没有高甘油三酯血症腰部表型的男性之间，平均HDL-胆固醇之间也存在显着差异（分别为32.8±14.2和42.1±±13.7 mg / dl; P = 0.04）。 2糖尿病，他汀类药物的使用和心力衰竭的病因。结论：高甘油三酸酯血症的腰部表型与心力衰竭男性的HDL-胆固醇水平降低显着相关。

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