• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sao Paulo Medical Journal >Association between asthma and female sex hormones
【24h】

Association between asthma and female sex hormones

机译：哮喘与女性性激素之间的关联

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de S?￡o Paulo (Unifesp). METHODS: We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS: The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS: The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-?± production, interferon-?3 expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted.
机译：背景与目的：在一些研究中已经评估了性激素与哮喘之间的关系。这篇评论文章的目的是研究在不同情况下（经前哮喘，使用口服避孕药，更年期，激素替代疗法和怀孕）哮喘与女性性激素之间的关系。设计与地点：对托坎汀斯联邦大学（UFT）和圣保罗大学（Unifesp）联邦医学文献的叙述性评论。方法：我们搜索了CAPES期刊门户，该门户是巴西的一个平台，可访问MEDLINE，PubMed，SciELO和LILACS数据库中的文章。根据医学主题词使用了以下关键字：哮喘，性激素，妇女和口服避孕药的使用。结果：性激素与哮喘之间的关联仍然不清楚。在成年人中，女性比男性更常见哮喘。另外，由于哮喘引起的死亡率在女性中明显更高。免疫系统受到性激素的影响：要么因为孕激素刺激孕激素诱导的阻断因子和Th2细胞因子，要么因为源自孕激素和雌激素的避孕药刺激转录因子GATA-3。结论：哮喘与女性性激素之间的关联仍然不清楚。我们推测雌激素波动是导致女性哮喘发作的原因。由于雌激素的抗炎作用，它降低了TNF-α的产生，干扰素-β3的表达和NK细胞的活性。我们建议应进行进一步研究，以突出促成这些相互作用的潜在生理病理机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号