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首页> 外文期刊>Pharmacogenomics and Personalized Medicine >Pharmacogenomic testing: aiding in the management of psychotropic therapy for adolescents with autism spectrum disorders
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Pharmacogenomic testing: aiding in the management of psychotropic therapy for adolescents with autism spectrum disorders

机译：药物基因组学测试：帮助自闭症谱系障碍青少年进行精神治疗

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Adolescents with autism have higher rates of anxiety than the general adolescent population. They often struggle to express psychological symptoms verbally where their symptoms may manifest as withdrawal and agitation. Adolescent patients with autism have higher rates of polypharmacy and high-risk psychiatric medication use (eg, atypical antipsychotics) than other patients with psychiatric illness. Primary care pediatricians are at the front lines of psychiatric management for patients with autism. Yet, they have inadequate access to pediatric psychiatry for complex medication management. Pharmacogenomic testing can provide personalized drug metabolism profiles for a majority of psychotropic medications. Primary care based pharmacogenomic testing for adolescents with autism on one or more psychiatric medications may help individualize and optimize complex medication regimens, while promoting drug safety.
机译：自闭症青少年比一般青少年的焦虑率更高。他们常常难以通过口头表达心理症状，其中症状可能表现为退缩和躁动。与其他患有精神病的患者相比，自闭症青少年患者的多药治疗和高危精神病药物使用率（例如非典型抗精神病药）更高。对于自闭症患者，初级保健儿科医生是精神病治疗的第一线。然而，他们无法获得复杂的药物管理所需要的儿科精神病学服务。药物基因组学测试可以为大多数精神药物提供个性化的药物代谢特征。对患有自闭症的青少年使用一种或多种精神药物进行基于初级保健的药物基因组学测试，可以帮助个性化和优化复杂的药物治疗方案，同时提高药物安全性。

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