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首页> 外文期刊>PLoS One >Maternal and Birth Characteristics and Childhood Embryonal Solid Tumors: A Population-Based Report from Brazil
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Maternal and Birth Characteristics and Childhood Embryonal Solid Tumors: A Population-Based Report from Brazil

机译：产妇和出生特征与儿童胚胎实体瘤：来自巴西的基于人口的报告

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Background Several maternal and birth characteristics have been reported to be associated with an increased risk of many childhood cancers. Our goal was to evaluate the risk of childhood embryonal solid tumors in relation to pre- and perinatal characteristics. Methods A case-cohort study was performed using two population-based datasets, which were linked through R software. Tumors were classified as central nervous system (CNS) or non-CNS-embryonal (retinoblastoma, neuroblastoma, renal tumors, germ cell tumors, hepatoblastoma and soft tissue sarcoma). Children aged 6 years were selected. Adjustments were made for potential confounders. Odds ratios (OR) with 95% confidence intervals (CI) were computed by unconditional logistic regression analysis using SPSS. Results Males, high maternal education level, and birth anomalies were independent risk factors. Among children diagnosed older than 24 months of age, cesarean section (CS) was a significant risk factor. Five-minute Apgar ≤8 was an independent risk factor for renal tumors. A decreasing risk with increasing birth order was observed for all tumor types except for retinoblastoma. Among children with neuroblastoma, the risk decreased with increasing birth order (OR = 0.82 (95% CI 0.67–1.01)). Children delivered by CS had a marginally significantly increased OR for all tumors except retinoblastoma. High maternal education level showed a significant increase in the odds for all tumors together, CNS tumors, and neuroblastoma. Conclusion This evidence suggests that male gender, high maternal education level, and birth anomalies are risk factors for childhood tumors irrespective of the age at diagnosis. Cesarean section, birth order, and 5-minute Apgar score were risk factors for some tumor subtypes.
机译：背景技术据报道，一些母婴特征与许多儿童期癌症的风险增加有关。我们的目标是评估与产前和围产期特征相关的儿童胚胎实体瘤的风险。方法使用两个基于人群的数据集进行个案队列研究，这两个数据集通过R软件链接在一起。肿瘤分为中枢神经系统（CNS）或非CNS胚胎（视网膜母细胞瘤，神经母细胞瘤，肾肿瘤，生殖细胞瘤，肝母细胞瘤和软组织肉瘤）。选择年龄小于6岁的儿童。针对潜在的混杂因素进行了调整。使用SPSS通过无条件逻辑回归分析计算出具有95％置信区间（CI）的几率（OR）。结果男性，较高的母亲教育程度和出生畸形是独立的危险因素。在被诊断为大于24个月大的儿童中，剖宫产（CS）是重要的危险因素。五分钟的Apgar≤8是肾肿瘤的独立危险因素。除视网膜母细胞瘤外，所有类型的肿瘤均随着出生顺序的增加而降低风险。在患有神经母细胞瘤的儿童中，风险随着出生顺序的增加而降低（OR = 0.82（95％CI 0.67–1.01））。 CS分娩的儿童除视网膜母细胞瘤以外的所有肿瘤的OR均略有增加。较高的母亲教育水平表明，所有肿瘤，中枢神经系统肿瘤和神经母细胞瘤的几率均显着增加。结论该证据表明，不论诊断年龄如何，男性性别，较高的母亲教育水平和出生畸形是儿童肿瘤的危险因素。剖宫产，出生顺序和5分钟Apgar评分是某些肿瘤亚型的危险因素。

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