• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pulmonary therapy. >The Role of the Body Clock in Asthma and COPD: Implication for Treatment
【24h】

The Role of the Body Clock in Asthma and COPD: Implication for Treatment

机译：人体时钟在哮喘和COPD中的作用：对治疗的意义

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Asthma exhibits a marked time of day variation in symptoms, airway physiology, and airway inflammation. This is also seen in chronic obstructive pulmonary disease (COPD), but to a lesser extent. Our understanding of how physiological daily rhythms are regulated by the circadian clock is increasing, and there is growing evidence that the molecular clock is important in the pathogenesis of these two airway diseases. If time of day is important, then it follows that treatment of asthma and COPD should also be tailored to the most efficacious time of the day, a concept known as ‘chronotherapy’. There have been a number of studies to determine the optimal time of day at which to take medications for asthma and COPD. Some of these agents are already used ‘chronotherapeutically’ in practice (often at night-time). However, several studies investigating systemic and inhaled corticosteroids have consistently shown that the best time of day to take these medications for treating asthma is in the afternoon or early evening and not in the morning, when these medications are often prescribed. Future, large, randomized, placebo-controlled studies of systemic and inhaled corticosteroids in asthma and COPD are needed to inform clinical practice.
机译：哮喘在症状，气道生理和气道炎症方面表现出明显的一天变化。这在慢性阻塞性肺疾病（COPD）中也可见，但程度较轻。我们对生理时钟如何由昼夜节律调节的理解正在增加，并且越来越多的证据表明分子钟在这两种气道疾病的发病机理中很重要。如果一天中的时间很重要，那么随之而来的是，哮喘和COPD的治疗也应针对一天中最有效的时间进行量身定制，这一概念被称为“计时疗法”。已经进行了许多研究来确定每天服用哮喘和COPD药物的最佳时间。在实践中，其中一些代理已“按时进行治疗”使用（通常在夜间使用）。但是，几项研究全身和吸入皮质类固醇激素的研究一致表明，每天服用这些药物治疗哮喘的最佳时间是下午或傍晚，而不是通常开处方的早晨。需要对哮喘和COPD中全身性和吸入性皮质类固醇激素进行未来的大型，随机，安慰剂对照研究，以指导临床实践。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号