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首页> 外文期刊>The Journal of Nutrition: Official Organ of the American Institute of Nutrition >Plasma Lycopene Concentrations in Humans Are Determined by Lycopene Intake, Plasma Cholesterol Concentrations and Selected Demographic Factors
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Plasma Lycopene Concentrations in Humans Are Determined by Lycopene Intake, Plasma Cholesterol Concentrations and Selected Demographic Factors

机译:人体中的血浆番茄红素浓度由番茄红素摄入量,血浆胆固醇浓度和选定的人口统计学因素确定

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Higher plasma lycopene concentrations have been associated with a reduced risk of several chronic diseases. Determinants of lycopene concentrations in humans have received limited attention. We had blood lycopene concentrations and lycopene consumption data available from 111 participants in a two-center cancer prevention trial involving β-carotene and examined determinants of plasma lycopene levels cross-sectionally. The median plasma lycopene level was 0.59 μmol/L (range 0.07–1.79). Low plasma concentrations of lycopene were associated with the following variables in univariate analyses: study site (Florida lower than Connecticut, P = 0.001), being nonmarried (P = 0.02), having lower income (P = 0.003), being nonwhite race/ethnicity (P = 0.03), having lower dietary lycopene intake (r = 0.29, P = 0.002), having lower plasma cholesterol (r = 0.43, P = 0.0001) and triglyceride levels (r = 0.26, P = 0.005), and consuming less vitamin C (r = 0.20, P = 0.03). Women had slightly higher plasma lycopene levels than men (0.65 vs. 0.58 μmol/L; P = 0.31), despite lower dietary intake of lycopene (1,040 vs. 1,320 μg/d; P = 0.50). Plasma lycopene levels did not differ in smokers and nonsmokers. In stepwise regression analyses, the determinants of plasma lycopene were plasma cholesterol, dietary lycopene, and marital status; these three variables explained 26% of the variance in plasma lycopene. Relatively few lifestyle and demographic factors were important determinants of plasma lycopene levels, with plasma cholesterol, marital status, and lycopene intake being of greatest importance.
机译:较高的血浆番茄红素浓度与几种慢性疾病的风险降低有关。人体中番茄红素浓度的决定因素受到的关注有限。在一项涉及β-胡萝卜素的两中心癌症预防试验中,我们从111名参与者中获得了血中番茄红素的浓度和番茄红素的消耗数据,并横断面检查了血浆番茄红素水平的决定因素。血浆番茄红素的中位水平为0.59μmol/ L(范围0.07-1.79)。番茄红素的血浆浓度低与单变量分析中的以下变量相关:研究地点(佛罗里达州低于康涅狄格州,P = 0.001),未婚(P = 0.02),收入较低(P = 0.003),非白人种族/种族(P = 0.03),饮食中番茄红素的摄入量较低(r = 0.29,P = 0.002),血浆胆固醇(r = 0.43,P = 0.0001)和甘油三酸酯水平较低(r = 0.26,P = 0.005),且消耗较少维生素C(r = 0.20,P = 0.03)。尽管血浆中番茄红素的摄入量较低(1,040 vs. 1,320μg/ d; P = 0.50),但女性血浆番茄红素水平略高于男性(0.65 vs. 0.58μmol/ L; P = 0.31)。吸烟者和不吸烟者的血浆番茄红素水平没有差异。在逐步回归分析中,血浆番茄红素的决定因素是血浆胆固醇,饮食中番茄红素和婚姻状况。这三个变量解释了血浆番茄红素变化的26%。相对很少的生活方式和人口统计学因素是血浆番茄红素水平的重要决定因素,血浆胆固醇,婚姻状况和番茄红素的摄入量是最重要的。

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