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首页> 外文期刊>The Internet Journal of Tropical Medicine >A Note On The Total Antioxidant Activity In The Subjects With Glucose-6-Phosphate Dehydrogenase Deficiency
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A Note On The Total Antioxidant Activity In The Subjects With Glucose-6-Phosphate Dehydrogenase Deficiency

机译：葡萄糖6-磷酸脱氢酶缺乏症患者总抗氧化活性的注意事项

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摘要

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited enzyme deficiency. This disorder causes hemolytic anemia, which is often enhanced by an identifiable chemical trigger or infection [1,2]. G6PD is the key rate-limiting enzyme in the pentose pathway and the expression of its gene has been shown to be redox-sensitive [3] Physiologically, G6PD plays an important role in cellular redox homeostasis, which is crucial for cell survival [4]. Cheng et al said that G6PD status determined the response of cells exposed to nitric oxide (NO) donor [4]. Overexpression of G6PD in vascular endothelial cells decreases reactive oxygen species accumulation in response to exogenous and endogenous oxidant stress and improves levels of bioavailable NO [5].
机译：6-磷酸葡萄糖脱氢酶（G6PD）缺乏症是常见的遗传性酶缺乏症。这种疾病会导致溶血性贫血，通常可识别的化学触发或感染会加剧溶血性贫血[1,2]。 G6PD是戊糖途径中的关键限速酶，其基因表达已被证明对氧化还原敏感[3]生理上，G6PD在细胞氧化还原稳态中起重要作用，这对于细胞存活至关重要[4] 。 Cheng等人说，G6PD的状态决定了暴露于一氧化氮（NO）供体的细胞的反应[4]。血管内皮细胞中G6PD的过表达减少了响应于外源性和内源性氧化应激的活性氧的积累，并提高了生物可利用的一氧化氮水平[5]。

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