Enhancement of Cortical GABAergic Function does not Account for the Anticonvulsant Effects of Midazolam, Isoflurane or Etomidate

Voss Logan J.; Sleigh James W.

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Enhancement of Cortical GABAergic Function does not Account for the Anticonvulsant Effects of Midazolam, Isoflurane or Etomidate

机译：皮质GABA能功能的增强不能解释咪达唑仑，异氟烷或依托咪酯的抗惊厥作用

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Background:Enhancement of cerebrocortical GABAergic inhibition is postulated as the main mechanism by which anesthetics inhibit seizures; however this has not been directly tested under controlled conditions. In this study we utilized the isolated cerebral cortex slice preparation and tested the anticonvulsant properties of three anesthetics with differing specificities for GABAergic activation and with various clinical and experimental anticonvulsant efficacy; midazolam, isoflurane and etomidate.

机译：背景：认为增强脑皮质GABA的抑制作用是麻醉药抑制癫痫发作的主要机制。但是，这尚未在受控条件下直接进行测试。在这项研究中，我们使用了分离的大脑皮层切片制剂，并测试了三种麻醉剂的抗惊厥特性，这些麻醉剂具有不同的GABA能激活特异性，并具有各种临床和实验的抗惊厥功效。咪达唑仑，异氟烷和依托咪酯。

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《The Open Anesthesia Journal》 |2010年第1期|共8页
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Voss Logan J.; Sleigh James W.;
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1. Enhancement of Cortical GABAergic Function does not Account for the Anticonvulsant Effects of Midazolam, Isoflurane or Etomidate [J] . Logan J. Voss, James W. Sleigh The Open Anesthesiology Journal . 2017,第1期

机译：皮质GABA能功能的增强不能解释咪达唑仑，异氟烷或依托咪酯的抗惊厥作用
2. Effects of anesthetic induction with midazolam-propofol and midazolam-etomidate on selected ocular and cardiorespiratory variables in clinically normal dogs [J] . Gunderson Erin G., Lukasik Victoria M., Ashton Marcella M., American Journal of Veterinary Research . 2013,第4期

机译：咪达唑仑-丙泊酚和咪达唑仑-依托咪酯麻醉诱导对临床正常犬选择的眼和心肺变量的影响
3. Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy. [J] . Leniger T, Wiemann M, Bingmann D, Cephalalgia . 2000,第6期

机译：GABA能抗惊厥药对4-氨基吡啶诱导的海马锥体细胞自发性GABA能超极化的不同作用-暗示它们在偏头痛治疗中的功效。
4. PROCEDURE TO ACCOUNT FOR NON-LINEAR EFFECTS IN EMPIRICAL TRANSFER FUNCTIONS [C] . Xu Luan, Jun Liang, Jin Cheng, Innovation, practice, safety . 2008

机译：经验转移函数中的非线性效应的计算方法
5. Brain cortical thickness in children with Attention-Deficit/Hyperactivity Disorder combined subtype: Effects of psychostimulant medication treatment and implications for neuropsychological functioning and behavior [D] . Bledsoe, Jesse C. 2012

机译：注意缺陷/多动障碍合并亚型儿童的大脑皮层厚度：精神刺激药物治疗的影响以及对神经心理学功能和行为的影响
6. Comparison of the Effects of Low-Dose Midazolam Magnesium Sulfate Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries [O] . Abbas Sedighinejad, Bahram Naderi Nabi, Mohammad Haghighi, 2016

机译：骨科手术中低剂量咪达唑仑硫酸镁瑞芬太尼和低剂量依托咪酯预防依托咪酯诱发的肌阵挛的效果比较
7. Enhancement of Cortical GABAergic Function does not Account for the Anticonvulsant Effects of Midazolam, Isoflurane or Etomidate~!2009-11-19~!2010-05-23~!2010-07-29~! [O] . Logan Voss 2010

机译：皮质加速功能的增强不考虑咪达唑仑，异氟醚或etoomidate的抗惊厥作用〜！2010-05-23〜！2010-07-29〜！

Enhancement of Cortical GABAergic Function does not Account for the Anticonvulsant Effects of Midazolam, Isoflurane or Etomidate

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