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首页> 外文期刊>The Open Mycology Journal >Engineered Keratinized Oral Mucosa Decreased C. albicans Transition Through the Production of Keratins 10, 14, 16, and 19 by Oral Epithelial Cells
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Engineered Keratinized Oral Mucosa Decreased C. albicans Transition Through the Production of Keratins 10, 14, 16, and 19 by Oral Epithelial Cells

机译：工程化的角蛋白化口腔粘膜通过口腔上皮细胞产生角蛋白10、14、16和19减少了白色念珠菌的转化

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The aim of this study was to evaluate the link between Candida albicans growth and dimorphism and the productionof keratins by oral epithelial cells. Various culture models (monolayer and non-keratinized and keratinized engineeredhuman oral mucosa) were produced and used for this purpose. Cell morphology, tissue structure, and the transitionof C. albicans were assessed following cell and tissue infections. Keratin production by epithelial cells exposed to C. albicanswas evaluated by Western blotting. Following contact with C. albicans, epithelial cells in the monolayer culturesshowed differentiating phenotypes. Compared to the keratinized tissue, the non-keratinized mucosa displayed visible disorganization.The transition of C. albicans from blastospore to hyphal form was significantly lower in the keratinized oralmucosa model. This was correlated with the high levels of differentiating (K10) and proliferating (K14, K16, and K19)keratins in the keratinized tissue, suggesting that tissue stratification contributes to controlling C. albicans pathogenicityvia keratin production. Thus, the transition of C. albicans from blastospore to hyphal form may be linked to keratin production.This may ultimately have implications in the control of oral candidiasis as well as in denture design to preventdenture stomatitis.
机译：这项研究的目的是评估白色念珠菌的生长和二态性与口腔上皮细胞产生角蛋白之间的联系。产生了多种培养模型（单层和非角化的和角化的工程化人口腔粘膜），并用于此目的。细胞和组织感染后，评估细胞形态，组织结构和白色念珠菌的转化。通过Western印迹评估暴露于白色念珠菌的上皮细胞的角蛋白产生。与白色念珠菌接触后，单层培养物中的上皮细胞表现出分化表型。与角化组织相比，未角化的粘膜表现出明显的无序性。在角化的口腔粘膜模型中，白色念珠菌从胚芽孢子向菌丝形式的转变显着降低。这与角化组织中高水平的分化（K10）和增生（K14，K16和K19）角蛋白相关，表明组织分层有助于通过角蛋白产生控制白色念珠菌的致病性。因此，白色念珠菌从芽孢杆菌向菌丝形式的转变可能与角蛋白的产生有关，这可能最终对控制口腔念珠菌病以及为防止义齿口腔炎的义齿设计产生影响。

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