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首页> 外文期刊>The Open Obesity Journal >Effects on Body Mass of Laboratory Rats after Ingestion of Drinking Water with Sucrose, Fructose, Aspartame, and Sucralose Additives
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Effects on Body Mass of Laboratory Rats after Ingestion of Drinking Water with Sucrose, Fructose, Aspartame, and Sucralose Additives

机译：摄入蔗糖，果糖，阿斯巴甜和三氯蔗糖添加剂的饮用水对实验大鼠体重的影响

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The excessive consumption of natural sweeteners is considered to be a major cause of increase in body mass. The authors wished to establish whether hypocaloric artificial sweeteners also promoted mass gain in laboratory rats (Harlan Wistar male rats). Ad libitum sweeteners were added to the drinking water of five groups of nine male rats each weighing circa 40g: Group 1, 15% fructose; group 2, 10% sucrose; group 3, 0.3% aspartame; group 4, 0.19% sucralose; and group 5 (control), ordinary drinking water. The daily volume of water consumption, the amount of ingested food, and gain of body mass were assessed during 73 days. Histological sections of the liver tissue of these rats were analyzed using Sudan and Hematoxylin-Eosin red staining. Results indicated that the fructose solution promoted the highest final gain in body mass, statistically different from the control and sucrose groups (p < 0.05). The caloric consumption was similar to that of the sucrose group, but different from that of the control and one of the groups consuming hypocaloric sweeteners, aspartame (p < 0.05). Rats that ingested sucrose solutions had the lowest final body mass in spite of the fact that their total caloric intake was one of the highest, and as mentioned, similar to fructose. Rats that drank water with hypo-caloric artificial sweeteners, aspartame and sucralose ingested the same amount of food, and the caloric intake was similar to the control group (p < 0.05). They were fatter than the control and sucrose groups, although their caloric consumption was lower than that of the fructose-drinking specimens, apparently confirming recent findings about glucose absorption with ingestion of artificial sweeteners. The behavior of the sucralose group, with a body mass higher than those of the control and sucrose groups, should be further studied, since this group showed a tendency to drink more water over time when compared to the control and aspartame groups. Liver-to-body mass ratios were not statistically different (p < 0.05) among the five groups, but both groups consuming hypocaloric sweeteners had slightly lower ratios than the sucrose, fructose, and control groups. As has been mentioned in previous research, ingestion of fructose solutions led to an increase of lipids in the liver tissue, in comparison with the other groups studied. Groups consuming hypocaloric sweeteners also showed a slight increase in lipid accumulation in liver tissue but not as much as the fructose-consuming group. The results of these experiments indicate the advisability of a long term experiment focusing on the ingestion of these sweeteners and their role in the increase in body mass.
机译：过量食用天然甜味剂被认为是增加体重的主要原因。作者希望确定低热量的人造甜味剂是否也促进实验室大鼠（Harlan Wistar雄性大鼠）的质量增加。将任意量的甜味剂添加到五组九只雄性大鼠的饮用水中，每只体重约40 g：第1组，15％果糖;第2组，10％蔗糖;第3组，阿斯巴甜0.3％;第4组，0.19％三氯蔗糖;第5组（对照组），普通饮用水。在73天内评估了每日的水消耗量，摄入的食物量以及体重增加。使用苏丹和苏木精-曙红染色对这些大鼠的肝脏组织的组织学切片进行分析。结果表明，果糖溶液可促进最高的最终体重增加，与对照组和蔗糖组在统计学上不同（p <0.05）。热量消耗与蔗糖组相似，但与对照组和消耗低热量甜味剂阿斯巴甜的一组不同（p <0.05）。摄入蔗糖溶液的大鼠的最终体重最低，尽管它们的总热量摄入量是最高的之一，并且与果糖相似。用低热量的人造甜味剂，阿斯巴甜和三氯蔗糖喝水的大鼠摄入了相同数量的食物，热量摄入与对照组相似（p <0.05）。它们的热量消耗低于果糖饮用的标本，尽管它们的热量消耗低于对照组和蔗糖组，但显然证实了最近关于摄入人造甜味剂吸收葡萄糖的发现。体重高于对照组和蔗糖组的三氯蔗糖组的行为应进一步研究，因为与对照组和阿斯巴甜组相比，该组随着时间的流逝显示出更多的饮水趋势。五组之间的肝-体质量比没有统计学差异（p <0.05），但是两个食用低热量甜味剂的组的比率均略低于蔗糖，果糖和对照组。如先前的研究所述，与其他研究组相比，果糖溶液的摄入导致肝脏组织中脂质的增加。食用低热量甜味剂的组在肝脏组织中的脂质蓄积也略有增加，但不如食用果糖的组少。这些实验的结果表明了一项长期实验的可取之处，该实验侧重于这些甜味剂的摄入及其在体重增加中的作用。

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