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Recent Advances in Childhood Brain Tumours

机译:儿童脑肿瘤的最新进展

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Brain tumours are the second commonest form of childhood malignancy. In Hong Kong, around 25 to 40 children below 15 years are diagnosed to have various types of brain tumours each year. But the term "brain tumour" in fact includes a heterogeneous group of tumours and their classification, diagnostic criteria, treatment modalities and outcome have undergone major changes in the past 2 decades. In this review, the objectives are to provide brief and update information on various developments in these areas. These will include: 1) the recent consensus in the classification of childhood brain tumours; 2) the current epidemiology of children with brain tumours, both locally and aboard; 3) the current hypotheses on the pathogenesis of some common paediatric brain tumours; 4) the common presenting features of the commonest types of childhood brain tumours locally; 5) the current diagnostic and therapeutic approaches and lastly; 6) the commonly encountered long-term sequalae among paediatric brain tumours survivors. In summary, many common forms of childhood brain tumours found locally can be cured nowadays. Current challenge is to further improve the outcome in those with poor outcome and minimise therapy related toxicity in those with good prognosis.
机译:脑肿瘤是儿童恶性肿瘤的第二常见形式。在香港,每年约有25至40名15岁以下的儿童被诊断患有各种类型的脑瘤。但是,“脑肿瘤”一词实际上包括了一组异质性肿瘤,在过去的20年中,它们的分类,诊断标准,治疗方式和结果发生了重大变化。在此审查中,目标是提供有关这些领域中各种发展的简要和最新信息。这些将包括:1)关于儿童脑肿瘤分类的最新共识; 2)目前本地和国外脑瘤儿童的流行病学; 3)关于一些常见的小儿脑肿瘤发病机理的最新假设; 4)当地最常见类型的儿童脑肿瘤的共同表现特征; 5)当前的诊断和治疗方法,最后; 6)小儿脑肿瘤幸存者中经常遇到的长期性角膜炎。总而言之,如今在当地可以发现许多常见的儿童脑肿瘤形式。当前的挑战是进一步改善预后较差的患者的预后,并使预后良好的患者的治疗相关毒性降至最低。

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