Antitubercular, antibacterial and antifungal activity of some pyridoquinazolones derivatives

Rachna Rai; S.P. Shrivastava

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Antitubercular, antibacterial and antifungal activity of some pyridoquinazolones derivatives

机译：一些吡啶并喹唑啉酮衍生物的抗结核，抗菌和抗真菌活性

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To purpose this goal our research affords are directed to find new chemical classes of anti-tubercular active agents with different mode of action’s. series of quinazoline IIIrd have been synthesized involving three synthetic steps and bioevaluated for their possible anti tubercular activity against H37 RV strain using Lowenstein Jenison medium and antimicrobial activity against E coli,staphylococcus Aures, Klebsidlla pneamoniar and also evaluated antifungal activity against Aspergillus Flavus,Aspergillus niger, and Trichoderma Viridae.

机译：为了达到这个目标，我们的研究方向是寻找具有不同作用方式的新化学类别的抗结核活性剂。已经合成了包括三个合成步骤的一系列喹唑啉IIIrd系列，并使用Lowenstein Jenison培养基对H37 RV菌株可能的抗结核活性以及对大肠杆菌，金黄色葡萄球菌，肺炎克雷伯菌的抗菌活性进行了生物学评估，还评估了对黄曲霉，黑曲霉的抗真菌活性和木霉属。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第3期|共5页
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Rachna Rai; S.P. Shrivastava;
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Antitubercular, antibacterial and antifungal activity of some pyridoquinazolones derivatives

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