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首页> 外文期刊>Journal of applied sciences research >Antihepatotoxic Effect of Some Natural Antioxidants Against Liver Damage InducedBy CCl4 in Rats
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Antihepatotoxic Effect of Some Natural Antioxidants Against Liver Damage InducedBy CCl4 in Rats

机译：某些天然抗氧化剂对CCl4诱导的大鼠肝损伤的抗肝毒性作用

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In recent years, the etiology of many diseases was attributed to increased oxidative stress and the role of diet or dietary constituents as natural antioxidants was magnified. The present study aims to investigate the antihepatotoxic effect of two antioxidant rich edible plants namely; Cichorium intybus (chicory) and Rhus coriaria (sumac) against carbon tetrachloride (CCl4) liver toxicity in rats as a model of increased oxidative stress. A model of chronic hepatic injury in rats was induced by carbon tetrachloride (CCl4) and then, the impact of chicory and sumac to antagonize this toxicity was evaluated. Four groups, each of eight rats were included. All animals except those in group one were administered orally with CCl4 (2 ml /Kg b.w.) in corn oil 1:1 V/V twice a week for four weeks. Group one was given only corn oil and served as a negative control group. Groups 2, 3 and 4 were pretreated with CCl4. Then the feeding experiment was started. Group one and group two were fed on standard diet so that group one was a negative control and group two was a positive control. Group three was fed on a standard diet + 150 g chicory per Kg diet while group four was given standard diet + 150 g sumac per Kg diet. After an experimental period of 8 weeks, blood was withdrawn after overnight fasting and biochemical parameters were analyzed. Activity of serum ALT and AST, serum total protein, serum albumin and serum glucose were estimated. Activity of antioxidant enzymes in liver tissue including superoxide dismutase, glutathione peroxidase and catalase were analyzed. Histopathological examination for liver tissue was done. Results obtained from this study revealed that there was an elevation in activities of s. AST, s. ALT, liver catalase and liver glutathione peroxidase as well as the concentration of s. glucose while there was a decline in the levels of s. total protein, s. albumin and the activity of liver superoxide dismutase in the positive control group. Also, the histopathological examination of liver tissue showed abnormal alterations. All these alternations in the previous parameters were more or less normalized in the groups that were fed on chicory and sumac. Thus it can be concluded that, addition of chicory and sumac to the diet can counteract the hepatotoxicity of CCl4. Consequently, chicory and sumac, those nutrients with high medicinal value, can be used for liver disorders as adjuvant therapy and for those who are exposed to increased oxidative stress that may affect their hepatic function.
机译：近年来，许多疾病的病因归因于氧化应激的增加，并且饮食或饮食成分作为天然抗氧化剂的作用被放大。本研究旨在研究两种富含抗氧化剂的食用植物的抗肝毒性作用。菊苣（Cichorium intybus）（变态）和大戟（Rus coriaria）（sumac）对大鼠四氯化碳（CCl4）肝毒性的作用是氧化应激增加的模型。用四氯化碳（CCl4）诱导大鼠慢性肝损伤模型，然后评估菊苣和漆树碱拮抗这种毒性的影响。分为四组，每组八只大鼠。除第一组动物外，所有动物每周两次在玉米油1：1 V / V中口服CCl4（2 ml / Kg b.w.）。第一组仅给予玉米油，并作为阴性对照组。第2、3和4组用CCl4预处理。然后开始进食实验。第一组和第二组以标准饮食喂养，因此第一组为阴性对照，第二组为阳性对照。第三组饲喂标准饮食+每千克饮食150 g菊苣，而第四组饲喂标准饮食+每千克饮食150 g漆树。经过8周的实验后，禁食过夜后抽血并分析生化参数。估计血清ALT和AST的活性，血清总蛋白，血清白蛋白和血糖。分析了肝组织中抗氧化酶的活性，包括超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶。进行肝组织的组织病理学检查。从这项研究中获得的结果表明，s的活性有所提高。 AST。 ALT，肝脏过氧化氢酶和肝脏谷胱甘肽过氧化物酶以及s的浓度。葡萄糖，而s水平下降。总蛋白阳性对照组的白蛋白和肝超氧化物歧化酶活性。另外，肝组织的组织病理学检查显示异常改变。在菊苣和漆树为食的组中，先前参数中的所有这些变化或多或少都被标准化了。因此可以得出结论，在饮食中添加菊苣和漆树可以抵消CCl4的肝毒性。因此，菊苣和漆树素，具有高药用价值的那些营养素，可用于肝脏疾病作为辅助治疗，也可用于那些暴露于氧化应激增加而可能影响其肝功能的人。

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