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首页> 外文期刊>Journal of Cardiovascular Disease Research >Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians
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Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians

机译：西北肥胖印第安人中丙二醛和某些抗氧化剂的比较研究

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Background: Obesity is one of the most common health problems in developed and developing nations like India. In addition, obesity is considered as a principal risk factor in the initiation of various non communicable chronic diseases such as dyslipidemia, atherosclerosis, cardiovascular, non-insulin dependent diabetes mellitus etc. The pathogenesis of these diseases is associated with oxygen-derived free radicals. Aim: The aim of the study was to analyze oxidative status in obese subjects with respect to normal healthy subjects. Material and Methods: The present study was performed in 50 obese men (BMI>46 kg/m2) and equal number of normal healthy men (BMI2) and the levels of malondialdehyde, antioxidant enzymes/molecules like superoxide dismutase, catalase reduced glutathione, glutathione reductase, glutathione peroxidase, antioxidant Vitamin-E and Vitamin-C along with total antioxidant activity were evaluated. Results: A significant increase (p46 kg/m2) due to alterations in the malondialdehyde and other oxidative stress markers such as Vitamin-E, Vitamin-C, Superoxide dismutase, catalase, reduced glutathione, glutathione reductase and glutathione peroxidase might be responsible for the etiology of diseases like diabetes, cancer arthritis, atherosclerosis etc. and therefore, obesity should be treated with the same attention of noncommunicable diseases like atherosclerosis, arthritis, diabetes, cancer etc.
机译：背景：肥胖是印度等发达国家和发展中国家最常见的健康问题之一。此外，肥胖被认为是引发各种非传染性慢性疾病如血脂异常，动脉粥样硬化，心血管疾病，非胰岛素依赖型糖尿病等的主要危险因素。这些疾病的发病机理与氧自由基有关。目的：该研究的目的是分析肥胖受试者相对于正常健康受试者的氧化状态。材料与方法：本研究是针对50名肥胖男性（BMI> 46 kg / m 2 ）和相等数量的正常健康男性（BMI2 ）以及丙二醛，抗氧化剂的水平进行的评估了酶/分子，如超氧化物歧化酶，过氧化氢酶还原型谷胱甘肽，谷胱甘肽还原酶，谷胱甘肽过氧化物酶，抗氧化剂维生素E和维生素C以及总抗氧化剂活性。结果：由于丙二醛和其他氧化应激标记（例如维生素E，维生素C，超氧化物歧化酶，过氧化氢酶，谷胱甘肽还原酶，谷胱甘肽还原酶）的改变，显着增加（p46 kg / m 2 ）谷胱甘肽过氧化物酶可能与糖尿病，癌症关节炎，动脉粥样硬化等疾病的病因有关，因此，肥胖症应与动脉粥样硬化，关节炎，糖尿病，癌症等非传染性疾病同等重视。

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