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Investigation of rotavirus and adenovirus antigens in patients with acute gastroenteritis

机译:急性胃肠炎患者轮状病毒和腺病毒抗原的调查

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Objective: Nowadays, viruses are the most common agents of acute gastroenteritis all over the world. Acute gastroenteritis, especially in children, is an important cause of mortality and morbidity. Both the lack of effective treatments as well as due to the unnecessary use of antibiotics, detection of viral agents in stool is important in terms of the epidemiology and monitoring of the disease. The purpose of this study is to determine the frequency of rotavirus and adenovirus in patients with acute gastroenteritis admitted to our hospital.Methods: Rotavirus and adenovirus 40/41 antigens were investigated by immunochromatographic method in stool samples of 2795 patients admitted to our hospital with the diagnosis of acute gastroenteritis between January 2010- December 2013.Results: Viral antigens were detected in 338 (12,1%) of the total 2795 samples. Rotavirus antigen was detected in 273 (9.8%), adenovirus in 36 (1.3%), both rotavirus and adenovirus in 29 (1.0%) of the patients. Of the cases who have positive viral antigen test, 154 (45.6%) were female, 184 (54.4%) were male and 198 (58.6%) were in the 0-2 age group. Total antigen positivity was more common in the late summer and autumn.Conclusion: Rotavirus is the most important agent in acute gastroenteritis in our hospital. More than half of patients were in the 0-2 years old group. Detection of viral agents in patients with acute gastroenteritis will allow early diagnosis and symptomatic treatment as well as will prevent empirically the use of antibiotics
机译:目的:当今,病毒是全世界急性胃肠炎的最常见病原。急性胃肠炎,尤其是儿童,是导致死亡和发病的重要原因。缺乏有效的治疗以及由于不必要地使用抗生素,从流行病学和疾病监测方面来说,检测粪便中的病毒制剂很重要。本研究的目的是确定我院收治的急性胃肠炎患者轮状病毒和腺病毒的发生率。方法:采用免疫色谱法对我院收治的2795例患者的粪便样本中轮状病毒和腺病毒40/41抗原进行检测。于2010年1月至2013年12月间诊断为急性肠胃炎。结果:在2795份样本中,有338份(12.1%)被检测出病毒抗原。其中有273例(9.8%)检出轮状病毒抗原,36例(1.3%)检出腺病毒,29例(1.0%)检出轮状病毒和腺病毒。在0-2岁年龄组中,病毒抗原测试阳性的病例中,女性154例(45.6%),男性184例(54.4%),198例(58.6%)。总抗原阳性在夏末和秋末较为普遍。结论:轮状病毒是我院急性胃肠炎最重要的治疗剂。超过一半的患者在0-2岁组中。在急性肠胃炎患者中检测病毒制剂将有助于早期诊断和对症治疗,并从经验上阻止抗生素的使用

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