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首页> 外文期刊>Journal of Molecular Biology Research >Study of Resistance to 82 Clinical Cases Enterobacteriaceae to Beta-lactam Antibiotics
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Study of Resistance to 82 Clinical Cases Enterobacteriaceae to Beta-lactam Antibiotics

机译：肠杆菌科细菌对β-内酰胺类抗生素耐药的82例临床研究

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Knowledge of antimicrobial resistance patterns in E. coli, the predominant pathogen associated with urinary tract infections (UTI) is important as a guide in selecting empirical antimicrobial therapy. To describe the antimicrobial susceptibility of E. coli associated with UTI in a major university hospital in Tehran (Iran), seventy-six clinical isolates of E. coli were studied for susceptibility to Beta-lactam antibiotics by the disc diffusion method and Minimal Inhibitory Concentrations determination. All isolates were resistant to ampicillin, amoxicillin and oxacillin. Resistance to the other tested antibiotics was shown to be 93.4% to cefradine, 76.3% to carbenicillin, 47.3% to cefazoline, 50% to cefalexin and 32.8% to cephalothin while 1.3% expressed resistance to cefoxitime, and 2.6% were resistant to ceftizoxime and ceftriaxone. Substrate hydrolysis by ultra violet spectroscopy showed that 87.4% harbored penicillinases, 9% produced cephlosporinases and 3.6% degraded both substrates. Clavulanic acid inhibited enzyme activity in 82.9%, of which 78.95% was penicillinases (group IIa) and 3.95% was cephalosporinases (group IIb) of the Bush classification system. These results indicate that E. coli can posses a variety of Beta-lactamases that are responsible for Beta-lactam resistance. Members of the family Enterobacteriaceae, particularly Escherichia coli is the most common causes of urinary tract infections in hospitals and societies. Beta-lactam antibiotics, particularly the third and fourth generation of cephalosporins are effective in treating these infections.
机译：大肠杆菌（与尿路感染（UTI）相关的主要病原体）的抗药性模式知识对于选择经验性抗微生物疗法具有重要的指导意义。为了描述在德黑兰（伊朗）的一家主要大学医院中与UTI相关的大肠杆菌的抗菌敏感性，通过圆盘扩散法和最小抑菌浓度研究了76种临床分离菌株对β-内酰胺类抗生素的敏感性。决心。所有分离株均对氨苄西林，阿莫西林和奥沙西林具有抗性。对其他测试抗生素的耐药性显示对头孢拉定的耐药性为93.4％，对羧苄青霉素的耐药率为76.3％，对头孢唑啉的耐药率为47.3％，对头孢氨苄的耐药性为50.8％，对头孢噻辛的耐药率为32.8％，而对头孢噻肟的耐药性为1.3％，对头孢唑肟的耐药率为2.6％。头孢曲松钠。紫外光谱分析的底物水解结果显示，含有87.4％的青霉菌酶，9％的头孢菌素酶和3.6％的底物降解。棒酸抑制酶的活性为82.9％，其中布什分类系统的青霉菌酶（IIa组）为78.95％，头孢菌素酶（IIb组）为3.95％。这些结果表明，大肠杆菌可以具有引起β-内酰胺抗性的多种β-内酰胺酶。肠杆菌科，特别是大肠杆菌的成员是医院和社会中泌尿道感染的最常见原因。 β-内酰胺类抗生素，特别是第三代和第四代头孢菌素可有效治疗这些感染。

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