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首页> 外文期刊>Journal of Natural Sciences Research >Studies of In vitro Antioxidant and Cytotoxic Activities of Extracts and Isolated Compounds from Parinari curatellifolia (Chrysobalanaceae)
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Studies of In vitro Antioxidant and Cytotoxic Activities of Extracts and Isolated Compounds from Parinari curatellifolia (Chrysobalanaceae)

机译：虎杖（Parinari curatellifolia）（金银花科）提取物和分离化合物的体外抗氧化和细胞毒活性研究

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摘要

Parinari curatellifolia (family: chrysobalanaceae) is a plant used in Nigerian folk medicine for treatment of cancer and other diseases. In our search for pharmacologically active compounds, we have isolated and characterized compounds through column chromatography and spectroscopic techniques (MS, NMR and IR). We have evaluated the in vitro antioxidant activity of the different extracts and the pure compounds using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical model. The in vitro cytotoxic activity of the extracts and the pure compounds using the sodium 3’-[1-(phenylamino-carbonyl) -3,4-tetrazolium]-bis-[4-methoxy-6-nitro] benzene sulfonic acid hydrate (XTT) colorimetric method on cervical cancer (HeLa) cell line have also been assessed. The extracts and pure compounds have displayed moderate to excellent antioxidant and cytotoxic activities. The biological results suggest that these compounds may be suitable candidates for further drug development and investigation. The results obtained have provided a promising scientific basis for the use of P. curatellifolia in traditional medicine for treatment of cancer. Keywords: Parinari curatellifolia, Cytotoxicity, HeLa Cell line, Antioxidant, DPPH Free Radical
机译：Parinari curatellifolia（科：chrysobalanaceae）是一种用于尼日利亚民间医学的植物，用于治疗癌症和其他疾病。在寻找药理活性化合物时，我们已通过柱色谱和光谱技术（MS，NMR和IR）对化合物进行了分离和表征。我们已经使用2，2-二苯基-1-picylhydrazyl（DPPH）自由基模型评估了不同提取物和纯化合物的体外抗氧化活性。使用3'-[1-（苯基氨基羰基）-3,4-四唑鎓]-双-[4-甲氧基-6-硝基]苯磺酸钠水合物的提取物和纯化合物的体外细胞毒活性（还评估了宫颈癌（HeLa）细胞系的XTT比色法。提取物和纯化合物已显示出中等至极好的抗氧化剂和细胞毒性活性。生物学结果表明这些化合物可能是进一步药物开发和研究的合适候选物。获得的结果为在传统医学中治疗癌症的P. curatellifolia提供了有希望的科学依据。关键词：虎杖，细胞毒性，HeLa细胞系，抗氧化剂，DPPH自由基

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