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首页> 外文期刊>Journal of Neuroscience and Behavioral Health >Lead toxicity and some subsets of motor skill: Comparative evaluation of adult and prenatally exposed rats
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Lead toxicity and some subsets of motor skill: Comparative evaluation of adult and prenatally exposed rats

机译：铅中毒和部分运动技能：成年和产前暴露大鼠的比较评价

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Research has shown that even low levels of lead (Pb) exposure are dangerous. Thus, Pb exposure/toxicity continues to be a leading environmental health issue for children and women of childbearing age. A variety of toxic effects caused by Pb exposure during gestation and early childhood have been reported in both human and animal studies.? Adult Wistar rats of both sexes were used for this study. They were housed in individual improvised cages and were given food and water?ad libitum. The animal room temperature was maintained at approximately 27?C with a 12 light/dark cycle. After the period of acclimatization, adult rats were randomly assigned into four groups of eight rats each (4 males and 4 females) viz; Adult exposed and control; prenatally exposed and control. The adult and prenatally groups received 2n mM lead acetate solution as sole drinking fluid for the duration of the experiment. The study showed significant (p ≤ 0.05) results in pups negative geotaxis and cliff avoidance and sex by measure interaction response to weight changes in the adult groups, while the adult negative geotaxis, cliff avoidance, pups’ righting reflex showed no significant value (p ≥ 0.05). The lead exposed group hastens the eruption of upper incisors and eye opening and delayed the ear unfolding. The present results suggest that the prenatal exposure to Pb, influences the rate of physical maturation and sensory motor reflexes in pups.
机译：研究表明，即使低水平的铅（Pb）暴露也是危险的。因此，铅的暴露/毒性仍然是儿童和育龄妇女面临的主要环境健康问题。在人类和动物研究中均已报道了在妊娠和儿童早期由于铅暴露而引起的多种毒性作用。两只成年的Wistar成年大鼠用于这项研究。他们被安置在简易的笼子里，随意进食和饮水。使动物室温保持在约27℃，以12个明/暗周期。适应期后，将成年大鼠随机分为四组，每组八只大鼠（雄性4只，雌性4只）。成人暴露和控制;产前暴露和控制。成人和产前组在实验期间接受2n mM乙酸铅溶液作为唯一的饮用液。该研究表明，通过测量成年组对体重变化的交互作用，幼犬的负地轴性和避免躲避悬崖以及性别的行为有显着的结果（p≤0.05），而成年性的负地轴性，避免躲避，小狗的扶正反射显示无显着性结果（p ≥0.05）。铅暴露组加剧了上门牙的萌发和眼睛张开，并延迟了耳朵的展开。目前的结果表明，产前暴露于Pb会影响幼仔的身体成熟和感觉运动反射率。

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