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首页> 外文期刊>Infection and immunity >Influence of genetic background on host resistance to experimental murine tularemia.
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Influence of genetic background on host resistance to experimental murine tularemia.

机译：遗传背景对宿主对实验鼠Tularemia的抵抗力的影响。

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The host response to experimental murine tularemia was examined in different inbred mouse strains. The kinetics of growth of Francisella tularensis live vaccine strain (LVS) in the livers and spleens of A and C57BL/6 mice were monitored, and it was observed that mice of the A strain were more susceptible to the proliferation of LVS than were C57BL/6 mice. The difference was most marked 5 days following infection, when the number of bacteria isolated from the spleens of A mice was found to exceed that of C57BL/6 mice by 100-fold. In addition, the C57BL/6 strain exhibited a more pronounced splenomegaly 8 days after infection than did the A strain. When the response of other inbred strains was evaluated by determining the splenic count of LVS on day 5 postinfection, several levels of antiularemic resistance were observed. Mice of the AKR, BALB/cBy, C57BL/10, and SJL strains were found to be most resistant, while SM mice were most susceptible to the proliferation of LVS. The DBA/2, CBA, 129, C3H/HeJ, and A strains expressed a resistance phenotype which was intermediate between the two extremes, with A and C3H/HeJ mice being somewhat more susceptible than DBA/2, CBA, or 129 mice. The trait of resistance or susceptibility was analyzed genetically in (C57BL/6 x A)F1 hybrid mice and in F2 generation and recombinant inbred (RI) mouse strains derived from C57BL/6 (resistant) and A (susceptible) strain progenitors. The F1 progeny exhibited a level of resistance to infection which was similar to that of the resistant parent. In both the F2 generation mice and the RI strains, a continuous spectrum of resistance levels was observed. The results of these experiments indicate that the genetic background of the host influences host resistance to experimental murine tularemia and that multiple genetic loci are involved in this response.
机译：在不同的近交小鼠品系中检查了宿主对实验鼠tularemia的反应。监测了土拉弗朗西斯菌活疫苗株（LVS）在A和C57BL / 6小鼠的肝脏和脾脏中的生长动力学，并且观察到A株的小鼠比C57BL /更易感染LVS 6只小鼠。当发现从A小鼠脾脏分离的细菌数比C57BL / 6小鼠的细菌数高100倍时，差异在感染后5天最为明显。另外，感染后8天，C57BL / 6菌株比A菌株表现出更明显的脾肿大。当通过确定感染后第5天LVS的脾脏计数来评估其他近交菌株的反应时，观察到了几种水平的抗阿勒莱姆耐药性。发现AKR，BALB / cBy，C57BL / 10和SJL菌株的小鼠具有最高的抵抗力，而SM小鼠最容易感染LVS的增殖。 DBA / 2，CBA，129，C3H / HeJ和A株表现出介于两个极端之间的抗性表型，其中A和C3H / HeJ小鼠比DBA / 2，CBA或129小鼠更易感。在（C57BL / 6 x A）F1杂种小鼠和F2代以及从C57BL / 6（抗性）和A（易感）品系祖细胞衍生的重组自交（RI）小鼠品系中，对抗性或敏感性进行了遗传分析。 F1后代表现出对感染的抗性水平，与抗性亲本相似。在F2代小鼠和RI菌株中，都观察到了连续的抗药性谱。这些实验的结果表明，宿主的遗传背景会影响宿主对实验鼠Tularemia的抗性，并且该反应涉及多个遗传基因座。

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