• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Susceptibility of Neisseria gonorrhoeae to protegrins.
【24h】

Susceptibility of Neisseria gonorrhoeae to protegrins.

机译：淋病奈瑟氏球菌对蛋白质的敏感性。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We developed a sensitive and quantitative radial diffusion method to ascertain the susceptibility of six strains of Neisseria gonorrhoeae to antimicrobial peptides derived from mammalian leukocytes. The test organisms included the well-characterized serum-resistant FA19 and serum-sensitive F62 strains plus four antibiotic-resistant clinical isolates. Although each N. gonorrhoeae strain was resistant to human neutrophil defensins, all six were exquisitely sensitive to protegrins, a family of small beta-sheet antimicrobial peptides recently identified in porcine leukocytes. Protegrin-treated N. gonorrhoeae became vacuolated and had striking membrane changes when viewed by transmission and scanning electron microscopy. Because low concentrations of protegrins can also inactivate Chlamydia trachomatis and human immunodeficiency virus, they show promise for development as topical agents to avert sexually transmitted diseases.
机译：我们开发了一种灵敏且定量的径向扩散方法，以确定淋病奈瑟菌的六种菌株对源自哺乳动物白细胞的抗菌肽的敏感性。测试生物包括特征明确的抗血清FA19和血清敏感F62菌株，以及四种抗药性临床分离株。尽管每个淋病奈瑟氏球菌菌株均对人嗜中性白细胞防御素有抗性，但所有六个淋病奈瑟菌均对蛋白凝集素非常敏感，protegrins是最近在猪白细胞中鉴定出的一个小β-折叠抗菌肽家族。当通过透射和扫描电子显微镜观察时，用蛋白原蛋白处理的淋病奈瑟氏球菌被空泡化并且具有显着的膜变化。由于低浓度的蛋白凝集素也可以灭活沙眼衣原体和人类免疫缺陷病毒，因此，它们有望发展成为可避免性传播疾病的局部用药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号