Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

Hongyan Diao; Masashi Kohanawa

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Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

机译：内源性白细胞介素6通过抑制肿瘤坏死因子α的产生在链球菌毒性休克综合征中起重要的保护作用。

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During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-α) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-α monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-α production in S. pyogenes infection.

机译：在白细胞介素6（IL-6）缺陷型小鼠的化脓性链球菌感染期间，血清肿瘤坏死因子α（TNF-α）水平，肌肉坏死和死亡均比感染白细胞升高。 C57BL / 6小鼠。抗TNF-α单克隆抗体治疗可降低感染的IL-6缺陷小鼠的死亡率和肌肉坏死。这些结果表明IL-6通过抑制 S中的TNF-α产生起关键的保护作用。化脓性感染。 展开▼

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《Infection and immunity》 |2005年第6期|共4页

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Hongyan Diao; Masashi Kohanawa;
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专利

1. Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production. [J] . D J Fast, P M Schlievert, R D Nelson Infection and immunity . 1989,第1期

机译：与毒性休克综合征相关的葡萄球菌和链球菌热原毒素是肿瘤坏死因子产生的有效诱因。

2. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG((R))); Role of mangiferin isolated from the extract. [J] . Garrido G, Delgado R, Lemus Y, Pharmacological research: The official journal of The Italian Pharmacological Society . 2004,第2期

机译：用印度芒果（Mangifera indica L.）的标准水提取物防止败血性休克并抑制巨噬细胞和小胶质细胞上的肿瘤坏死因子α和一氧化氮的产生（VIMANG（R））;从提取物中分离出的芒果苷的作用。

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机译：粘附分子淋巴细胞功能相关抗原1在中毒性休克综合征毒素1诱导的人类单核细胞分泌的肿瘤坏死因子α和白介素1β的作用。

4. Pravastatin and Rosiglitazone May Attenuate Coronary Artery Disease by Decreasing Interferon-gamma, Tumor Necrosis Factor-alpha, Interleukin-6, Macrophage Chemotactic Protein-1, C-Reactive Protein, and Increasing Interleukin-4 [C] . L.G. Tan, S.A. Tan, L.S. Berk International Congress on Coronary Artery Disease . 2007

机译：普伐他汀和罗格列酮可以通过减少干扰素-γ，肿瘤坏死因子-α，白细胞介素-6，巨噬细胞趋化蛋白-1，C反应蛋白和增加白细胞介素-4

5. Does Lidocaine Reduce the Release of Interleukin-6 and Tumor Necrosis Factor-alpha in MC1R siRNA Transfected Melanocytes in Cell Culture? [D] . DeLaria, Angela D. 2016

机译：利多卡因是否能减少细胞培养MC1R siRNA转染的黑素细胞中白细胞介素6和肿瘤坏死因子-α的释放？

6. Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production [O] . Hongyan Diao, Masashi Kohanawa 2005

机译：内源性白细胞介素6通过抑制肿瘤坏死因子α的产生在链球菌毒性休克综合征中起重要的保护作用。

7. Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production [O] . Diao, Hongyan, Kohanawa, Masashi 2005

机译：内源性白细胞介素6通过抑制肿瘤坏死因子α的产生在链球菌毒性休克综合征中起重要的保护作用。

8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

1. 侵袭性A族链球菌感染和链球菌性中毒性休克综合征的有关问题 [J] . 徐大麟 ,徐志一 . 国外医学：内科学分册 . 1996,第002期

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3. 基质金属蛋白酶和肿瘤坏死因子释放酶选择性多肽抑制剂HQ1～HQ4对内毒素休克的保护作用的研究 [J] . 邱郑 ,胡加亮 ,吴海春 . 药物生物技术 . 2012,第006期

4. 严重烫伤大鼠休克期淋巴循环动力学及淋巴液中肿瘤坏死因子α和白细胞介素6、8水平的变化 [J] . 肖虎 ,王德昌 ,冷向峰 . 中华烧伤杂志 . 2005,第002期

5. 以多发性坏疽性臁疮为主要表现的链球菌相关中毒性休克综合征一例 [J] . 鲁伟峰 ,娄子轩 ,李军 . 中华皮肤科杂志 . 2021,第008期

6. 基质金属蛋白酶和肿瘤坏死因子释放酶选择性多肽抑制剂对内毒素休克的保护作用 [C] . Qiu Zheng ,邱郑 ,HU Jialiang . 2012‘中国生物药物创新研究论坛 . 2012

7. Ⅳ型分泌系统在高致病性2型猪链球菌引发链球菌中毒性休克综合征中作用的研究 [A] . 赵岩 . 2011

1. 链球菌中毒性休克综合征 [P] . 中国专利： CN112449603A . 2021-03-05

2. 检测脓毒症或脓毒性休克（SS）患者血浆中的循环组蛋白H3和H2B的基于质谱的方法 [P] . 中国专利： CN110325861A . 2019-10-11

3. RECOMBINANT FRAGMID DNA pHEN-TAB CONTAINING HUMAN SINGLE-STRAND ANTIBODY GENE, CAPABLE OF BINDING OF HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT Escherichia coli BACTERIA STRAIN AS PRODUCER OF HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT SOLUBLE HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA [P] . 外国专利： RU2307163C2 . 2007-09-27

机译：包含人类单链抗体基因的重组fragmidid DNA苯丙氨酸表位，能够结合人类肿瘤坏死因子α;重组大肠杆菌作为人单链抗体抗人肿瘤坏死因子α的生产者;重组抗人类肿瘤坏死因子α的人类单链抗体

4. Recombinant phagemid DNA PHEN-TAB, containing the gene of single chain human antibodies are capable of binding tumor necrosis factor alpha RIGHTS; Recombinant strains of bacteria ESCHERICHIA COLI-single-chain antibody PRODUCER AGAINST HUMAN SCTAB tumor necrosis factor alpha RIGHTS; Recombinant soluble single-chain antibody AGAINST HUMAN SCTAB tumor necrosis factor alpha RIGHTS [P] . 外国专利： RU2005129664A . 2007-03-27

机译：含有单链人抗体基因的重组噬菌粒DNA PHEN-TAB能结合肿瘤坏死因子αRIGHTS。埃希氏菌属大肠杆菌单链抗体生产者抗人SCTAB肿瘤坏死因子αRIGHTS的重组菌株;重组可溶性单链抗体抗人SCTAB肿瘤坏死因子αRIGHTS

5. PROCESS FOR THE PURIFICATION OF TUMOR NECROSIS FACTORS AND FOR THE PRODUCTION OF RECOMBINANT DNA MOLECULES THAT ENCODE COMPOUNDS SIMILAR TO TUMOR NECROSIS FACTORS AND TUMOR NECROSIS FACTORS [P] . 外国专利： PT81754B . 1987-12-30

机译：纯化肿瘤坏死因子和生产编码类似于肿瘤坏死因子和肿瘤坏死因子的化合物的重组DNA分子的方法

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Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

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