Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity <em>via</em> sequential multi-component reaction in PEG-400 as a biodegradable solvent

Ensieh Safari; Ammar Maryamabadi; Alireza Hasaninejad

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Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

机译：通过连续多组分反应在可生物降解溶剂PEG-400中高效地一锅合成具有骨架多样性的新型双螺硫辛多

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A green and efficient one-pot, sequential, multi-component protocol has been developed for the synthesis of some novel symmetrical bis-spirooxindole derivatives from the reaction of isatins, dihalides, malono derivatives and C–H activated carbonyl compounds or ketene aminal derivatives in the presence of potassium carbonate (K₂CO₃) in polyethylene glycol 400 (PEG-400) as a biodegradable polymeric solvent at room temperature. In this research, a variety of bis-spiro-indoline-pyranopyranes, bis-spiro-indoline-chromenes, bis-spiro-indoline-pyrido-pyrimidines, bis-spiro-indoline-imidazo-pyridines and bis-spiro-indoline-pyridines were obtained with excellent yields within short reaction time and without chromatographic separation.

机译：已开发出一种绿色高效的一锅，顺序，多组分方案，该方案用于从靛红，二卤化物，丙二酸衍生物和CH活化的羰基化合物或乙烯酮缩醛衍生物反应中合成一些新颖的对称双螺氧并吲哚衍生物。聚乙二醇400（PEG-400）中碳酸钾（K _{2 CO _{3 ）的存在在室温下可生物降解的聚合物溶剂。在这项研究中，各种双-螺-吲哚-吡喃并吡喃，双-螺-吲哚并-色胺，双-螺-吲哚并-吡啶-嘧啶，双-螺-吲哚并-咪唑并吡啶和双-螺-吲哚并吡啶在短反应时间内以优异的收率获得了目标化合物，无需色谱分离。}}

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《RSC Advances》 |2017年第63期|共10页
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Ensieh Safari; Ammar Maryamabadi; Alireza Hasaninejad;
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1. Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent [J] . Safari Ensieh, Maryamabadi Ammar, Hasaninejad Alireza RSC Advances . 2017,第63期

机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂
2. Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature [J] . Hasaninejad Alireza, Beyrati Maryam RSC Advances . 2018,第4期

机译：环保聚乙二醇（PEG-400）：室温下的单罐的绿色反应介质，四组分合成新型不对称双螺氧肟衍生物
3. Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature [J] . Alireza Hasaninejad, Maryam Beyrati RSC Advances . 2018,第4期

机译：环保型聚乙二醇（PEG-400）：一种绿色反应介质，可在室温下一锅四组分合成新型不对称双螺并氧杂吲哚衍生物
4. Highly efficient, one-pot, solvent-free synthesis of highly substituted imidazoles using molecular iodine as catalyst [C] . Yi-Ming Ren, Chun Cai International Conference on Chemical, Material and Metallurgical Engineering . 2012

机译：使用分子碘作为催化剂高效，单罐，无溶剂合成高度取代的咪唑
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo34-bpyridin-6(7H)-one Derivatives [O] . Xiaoxing Zhong, Guolan Dou, Deming Wang 2013

机译：聚乙二醇（PEG-400）：一种高效且可循环利用的反应介质用于合成吡唑并34-b吡啶-6（7H）-一衍生物
7. Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent [O] . Ensieh Safari, Ammar Maryamabadi, Alireza Hasaninejad 2017

机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂

Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

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