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首页> 外文期刊>Balkan journal of medical genetics: BJMG >Increased expression of pentraxin 3 in placental tissues from patients with unexplained recurrent pregnancy loss
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Increased expression of pentraxin 3 in placental tissues from patients with unexplained recurrent pregnancy loss

机译：从未解释的复发性妊娠损失的患者中胎盘组织中五胞苷3表达增加

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Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a evolutionarily conserved multimeric pattern recognition receptor involved in the humoral component of the innate immune system. Pentraxin 3 is released when tissue is stressed or damaged, and interacts with many different ligands. Pentraxin 3 exerts a pivotal role both as a regulator and as an indicator of inflammatory response in the pathogenesis of many diseases such as sepsis, vasculitis and preeclampsia. Uncontrolled inflammatory response is considered a major cause of unexplained recurrent pregnancy loss (URPL). We determined the PTX3 messenger ribonucleic acid (mRNA) and protein expression levels in placentai tissues from 50 women with URPL, and made comparison with those in 50 age-matched control subjects. In quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry analyses, PTX3 mRNA and protein levels, respectively, were significantly increased in URPL patients compared with their respective controls (p = 0.0001). Although no significant correlations were identified between PTX3 expression levels and clinical parameters such as maternal age, numbers of previous pregnancy losses, and gestational age at miscarriage, PTX3 mRNA expression was significantly higher in patients with no live births than in women with previous live births (p = 0.0001). Our study suggests that tissue-specific expression of PTX3 is associated with URPL. Further larger studies are required to determine whether PTX3 expression can be used as a biomarker to manage URPL in routine clinical practice.
机译：Pentraxin 3（PTX3）是长五花素亚家族的原型构​​件，是参与先天免疫系统的体液组分的进化保守的多聚体模式识别受体。当组织受到压力或损坏时，释放五星素3，并与许多不同的配体相互作用。五星素3作为调节剂施加枢轴作用，作为许多疾病的发病机制中炎症反应的指标，如败血症，血管炎和预普拉明血症。不受控制的炎症反应被认为是无法解释的复发性妊娠损失（URPL）的主要原因。我们确定PTX3信使核糖核酸（mRNA）和胎儿组织中的50个患有URPL的组织中的蛋白表达水平，并与50岁匹配对照受试者的那些进行比较。在定量实时聚合酶链反应（QRT-PCR）和免疫组织化学分析中，与其各自对照相比，URPL患者分别显着增加，PTX3 mRNA和蛋白质水平显着增加（P = 0.0001）。尽管在PTX3表达水平和诸如孕产妇年龄的临床参数之间没有鉴定显着的相关性，但之前的妊娠损失的数量和流产的孕龄，但PTX3 mRNA表达在没有以前活产出生的妇女的患者患者显着高于患者（ p = 0.0001）。我们的研究表明，PTX3的组织特异性表达与URPL有关。需要进一步的更大的研究来确定PTX3表达是否可以用作生物标志物，以管理常规临床实践中的URPL。

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