• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Biotechnology >Co-administration of Vitamins E and C protects against stress-induced hepatorenal oxidative damage and effectively improves lipid profile at both low and high altitude
【24h】

Co-administration of Vitamins E and C protects against stress-induced hepatorenal oxidative damage and effectively improves lipid profile at both low and high altitude

机译：维生素E和C的共同施用，可防止应力诱导的肝脏氧化损伤，并有效改善低空和高空的脂质曲线

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study?was?to evaluate the exhaustive exercise induced stressful effect as well as parallel administration of vitamins E and C mediated protective effect on hepatorenal functions in rats native to low altitude (LA) and high altitude (HA). In both LA and HA areas, native wistar rats of each area were divided into three groups each of 6 rats, which include non-stress control, forced swimming-induced experimental stress and experimental stress plus vitamin E and C treatment. At the end of the experiment, blood and tissue (liver and kidney) samples were obtained and subjected to different analyses of liver and kidney functions. Rats?at HA had similar baseline levels of organ function key parameters and lipid metabolism profiles, but have decreased levels of antioxidant markers with an increased level of lipid peroxidation when compared to LA rats. Exhaustive swimming exercise?induced stressful damage in liver and kidney of rats at both altitudes as indicated by significant increases in serum levels of enzymatic markers and decrease in tissue antioxidant defense system with a bigger magnitude of changes to occur in the high-altitude area. Also at LA,?forced swimming exercise resulted in?significant increases in serum levels total cholesterol (TChol), triacylglycerides (TAG) and high-density lipoprotein cholesterol (HDL) levels, but at HA?it resulted in?significant decreases in serum levels of TChol and low-density lipoprotein (LDL) with a significant increase in HDL.?Pre- and co-treatment with vitamins E and C improved the levels of all tissue function markers and significantly attenuated the exhaustive exercise induced oxidative stress in the liver and/or the kidneys, resulting in further decrease in?TChol and LDL levels?in both altitude areas with a better response in the low-altitude area.?These novel findings may play an important role in the human pathophysiology and treatment at different altitudes.
机译：这项研究的目的是？为了评估详尽的运动诱导的压力效应以及平行于维生素E和C介导的保护作用对低海拔（LA）和高海拔（HA）的大鼠的肝肾功能的保护作用。在La和Ha地区，每个区域的天然Wistar大鼠分为6只大鼠中的三组，包括非应力控制，强制游泳诱导的实验应力和实验应力加维生素E和C治疗。在实验结束时，获得血液和组织（肝脏和肾脏）样品并进行肝肾功能的不同分析。大鼠？在HA具有类似的基线水平的器官功能键参数和脂质代谢谱的抗氧化标志物水平降低，与La大鼠相比，脂质过氧化水平增加。详尽的游泳运动？在高度血清酶标水平的显着增加和组织抗氧化防御系统的显着增加，诱导了两次大鼠肝肾的压力损伤，并且在高空区域中发生更大的变化幅度较大的变化。同样在La，强制游泳运动导致血清水平总胆固醇（TCHOL），三酰基甘油（标签）和高密度脂蛋白胆固醇（HDL）水平的显着增加，但在HA？它导致血清水平显着降低用维生素E和C的HDL和CO-COMED升高的TCHOL和低密度脂蛋白（LDL）改善了所有组织功能标记的水平，并显着减弱了肝脏中的详尽锻炼诱导的氧化应激。 /或肾脏，导致进一步减少？TCHOL和LDL水平？在低海拔地区具有更好的反应的海拔地区。这些新发现可能在不同高度的人体病理生理学和治疗中起重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号