• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Egyptian Informatics Journal >An efficient methodology for discovering both of gene-environment interactions and gene-gene interactions causing genetic diseases
【24h】

An efficient methodology for discovering both of gene-environment interactions and gene-gene interactions causing genetic diseases

机译：一种有效的方法，用于发现基因环境相互作用和引起遗传疾病的基因 - 基因相互作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genetic diseases are one of the most critical diseases facing human societies, their risk lies in the transmission of genetic characteristics from one generation to another, where the imbalance of these characteristics leads to an unhealthy offspring, which negatively affects the effort of this offspring and its services to society. Genetic disease is caused by a mutation in the Deoxyribonucleic Acid (DNA), these genetic mutations are generated by nonlinear interactions between two or more genes and / or environmental exposures. The aim of this paper is to discover both of gene-environment interactions and gene-gene interactions causing a genetic disease, the proposed methodology is based on both of the filter and wrapper feature selection methods, it uses the filter method using a Relief algorithm to detect the gene-environment interactions, wrapper method using genetic algorithm to discover gene-gene interactions, and classification decision tree algorithm to generate the conditional rules of gene-gene interactions. It has been evaluated using many different classifier models on four benchmark databases, and compared its performance with an Apriori algorithm for generating rules of gene-gene interactions, the proposed methodology achieved the highest performance and better classification accuracy on all databases containing patients affected by gene-environment interactions or gene-gene interactions or both of gene-environment and gene-gene interactions.
机译：遗传疾病是人类社会面临最关键的疾病之一，其风险在于将遗传特征传播到另一代的遗传特征，其中这些特征的不平衡导致了一个不健康的后代，这对该后代的努力产生了负面影响对社会的服务。遗传疾病是由脱氧核糖核酸（DNA）的突变引起的，这些遗传突变由两种或多种基因和/或环境暴露之间的非线性相互作用产生。本文的目的是发现基因环境相互作用和基因 - 基因相互作用导致遗传疾病，所提出的方法基于两个过滤器和包装器特征选择方法，它使用滤波器方法使用浮雕算法检测基因 - 环境相互作用，使用遗传算法发现基因相互作用的包装方法，以及分类决策树算法生成基因基因相互作用的条件规则。已经在四个基准数据库上使用许多不同的分类器模型进行了评估，并将其与APRIORI算法进行了用于产生基因基因相互作用的规则，所提出的方法在含有受基因影响的所有数据库上实现了最高的性能和更好的分类准确性 - 环境相互作用或基因 - 基因相互作用或基因环境和基因 - 基因相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号