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Docetaxel-loaded SiO2@Au@GO core–shell nanoparticles for chemo-photothermal therapy of cancer cells

机译:多西紫杉醇加载的SiO2 @ Au @ Go核 - 壳纳米粒子,用于癌细胞的化学光热疗法

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The multifunctional antitumor SiO _(2) @Au@GO core–shell nanoparticles (NPs) have been fabricated for serving as drug nanocarrier and photothermal inducer. The core–shell NPs exhibited high loading capacity of docetaxel (Dtxl) and pH-dependent drug release property as well as low cytotoxicity (concentration < 0.2 mg mL ~(?1) ). Compared with chemotherapy alone, human prostate cancer cell incubated with Dtxl-loaded SiO _(2) @Au@GO NPs in vitro were found to have undergone morbidity on exposure to near-infrared (NIR) light (780 nm, 5 W cm ~(?2) ). It is expected that the multifunctional nanoparticles with unique core–shell structure will lead to new opportunities in nanomedicine.
机译:已经制造了多功能抗肿瘤SiO _(2)@ Au @ Go Core-Shell纳米粒子(NPS),用于用作药物纳米载体和光热诱导剂。核心壳NPS表现出高负荷能力的多西紫杉醇(DTX1)和pH依赖性药物释放性能以及低细胞毒性(浓度<0.2mg ml〜(α1))。与单独的化疗相比,与DTXL负载的SIO _(2)孵育的人前列腺癌细胞_(2)@ AU @ GO NPS在体外,在暴露于近红外(NIR)光(780nm,5W cm〜)的情况下发生了发病率。 (?2))。预计,具有独特核心壳结构的多功能纳米颗粒将导致纳米医生的新机会。

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