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首页> 外文期刊>American Journal of Immunology >Chronic and Acute Effect of Tramadol Intoxication on Some Immunological Parameters
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Chronic and Acute Effect of Tramadol Intoxication on Some Immunological Parameters

机译：曲马多的慢性和急性效应于一些免疫参数

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Tramadol intoxication is rapidly on the increase in Nigeria with unestablished short-term and long-term effects. The study was aimed at elucidating the dose-dependent effect of acute or chronic tramadol intoxication on some immunological parameters using male rats ( Rattus norvegicus ). A total of fifty adult rats were used for the study as indicated by Mead's Resource Equation. The study consisted of acute and chronic categories of fifty adult rats randomly pair-divided into groups of six rats each. The acute phase consisted of a control group of 6 rats administered with normal saline solution and a treatment group of 6 rats administered with lethal dose of tramadol. The chronic phase comprised of control group of 6 rats and 3 tramadol-dependent groups of 6 rats each administered orally with 50, 100 and 200 mg/kg of tramadol for a period of 90 days respectively. Student t -test, one-way Anova and Pearson correlations were the statistical tools used for the data analysis employing JMP statistical discovery? software version 14.1. Blood samples were collected by cardiac puncture for immunological examination using World Health Organization (WHO) approved methods. The study revealed that concentrations IgG, IgM and CD4 were significantly elevated (p0.05) in the acute treatment group compared with the controls. However, the chronic phase of the study showed a progressive significant increase (p0.05) in CD4 count. Conclusively, the study has demonstrated that tramadol intoxication has the preponderances of altering the immune apparatuses of the body.
机译：曲马多的中毒正在迅速增加尼日利亚的增加，但不合作的短期和长期影响。该研究旨在阐明使用雄性大鼠（Rattus Norvegicus）的一些免疫参数对一些免疫参数的剂量依赖性效果。如米德资源方程所示，共有50例成年大鼠用于研究。该研究由五十成年大鼠的急性和慢性类别组成，随机分成六只大鼠组。急性相由施用的6只大鼠的对照组组成，并用致命剂量的曲马多给予的6只大鼠的治疗组。由6只大鼠的对照组组成的慢性相和6只大鼠的3只大鼠的依赖性组分别施用50,100和200mg / kg曲马多，分别为90天。学生T -Test，单向ANOVA和Pearson相关性是用于采用JMP统计发现的数据分析的统计工具？软件版本14.1。通过世界卫生组织（世卫组织）批准的方法，通过心脏穿刺进行免疫检查的血液样品。该研究表明，与对照相比，急性治疗组中浓度IgG，IgM和CD4显着升高（P＆GT; 0.05）。然而，该研究的慢性阶段表明CD4计数中的逐渐显着增加（P＆GT; 0.05）。结论，该研究表明，曲马多的中毒具有改变身体免疫装置的优势。

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