Environmental Xenobiotics May Disrupt Normal Endocrine Function by Interfering with the Binding of Physiological Ligands to Steroid Receptors and Binding Proteins

Benjamin J. Danzo

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Environmental Xenobiotics May Disrupt Normal Endocrine Function by Interfering with the Binding of Physiological Ligands to Steroid Receptors and Binding Proteins

机译：环境异物可能会干扰生理配体与类固醇受体和结合蛋白的结合，从而破坏正常的内分泌功能。

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The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics (present at a concentration of 100 M) exert their action through steroid-mediated pathways, we examined their ability to inhibit the binding of [3~H]physiological ligands (present at a concentration of 7 nM) to the androgen and estrogen receptors, rat androgen-binding protein (ABP), and human sex hormone-binding globulin (hSHBG).

机译：野外雄性和雌性动物生殖系统的破坏被归因于环境化学物质（异生物素）。如果调节这些系统的类固醇激素依赖性过程受到损害，则可以预见镜面改变的效果。为了确定异种生物（浓度为100 M）是否通过类固醇介导的途径发挥作用，我们检查了它们抑制[3〜H]生理配体（浓度为7 nM）与雄激素结合的能力。雌激素受体，大鼠雄激素结合蛋白（ABP）和人性激素结合球蛋白（hSHBG）。

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《Environmental Health Perspectives》 |1997年第3期|p.294-301|共8页
作者
Benjamin J. Danzo;
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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境科学、安全科学;预防医学、卫生学;
关键词
androgen-binding protein; androgen receptor; estrogen receptor;

机译：雄激素结合蛋白雄激素受体雌激素受体;

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专利

1. ENVIRONMENTAL XENOBIOTICS MAY DISRUPT NORMAL ENDOCRINE FUNCTION BY INTERFERING WITH THE BINDING OF PHYSIOLOGICAL LIGANDS TO STEROID RECEPTORS AND BINDING PROTEINS [J] . Danzo BJ. Environmental Health Perspectives . 1997,第3期

机译：环境异种药物可能会干扰生理性液体与类固醇受体和蛋白质的结合，从而破坏正常的内分泌功能
2. Impact of induced fit on ligand binding to the androgen receptor: A multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals [J] . Lill MA, Winiger F, Vedani A, Journal of Medicinal Chemistry . 2005,第18期

机译：诱导适应对配体与雄激素受体结合的影响：多维QSAR研究，预测环境化学物质的内分泌干扰作用
3. Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein. [J] . Norman AW, Ishizuka S, Okamura WH The Journal of Steroid Biochemistry and Molecular Biology . 2001,第1a5期

机译：维生素D内分泌系统的配体：不同的形状可作为基因组和快速反应受体的激动剂和拮抗剂，或血浆维生素D结合蛋白的配体。
4. BIOASSAYS FOR THE IDENTIFICATION OF XENOBIOTICS INTERFERING WITH STEROID MODULATING ENZYMES: DISRUPTION OF KEY REGULATORS OF ENDOCRINE FUNCTIONS [C] . Alex Odermatt International Conference on Endocrine Disruptors . 2012

机译：用于鉴定Xenobiotics干扰类固醇调节酶的生物测定：内分泌功能的关键调节因子的破坏
5. Ligand-assisted protein structure characterization as a method for exploring the binding and functional motifs of ligands on the CB2 cannabinoid receptor 2. [D] . Zhou, Han. 2014

机译：配体辅助的蛋白质结构表征，作为探索CB2大麻受体2上配体的结合和功能性基序的方法。
6. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. [O] . B J Danzo 1997

机译：环境异物可能会干扰生理配体与类固醇受体和结合蛋白的结合从而破坏正常的内分泌功能。
7. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. [O] . Danzo, B J 1997

机译：环境异物可能会干扰生理配体与类固醇受体和结合蛋白的结合，从而破坏正常的内分泌功能。
8. Role of Low Frequency Collective Modes in Biological Function: Ligand Binding and Cooperativity in Calcium-Binding Proteins [R] . Trewhella, J. 2001

机译：低频集体模式在生物功能中的作用：钙结合蛋白的配体结合和协同作用

Environmental Xenobiotics May Disrupt Normal Endocrine Function by Interfering with the Binding of Physiological Ligands to Steroid Receptors and Binding Proteins

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