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首页> 外文期刊>Experimental Animals >Maternal Environment Alters Social Interactive Traits But Not Open-field Behavior In Fischer 344 Rats
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Maternal Environment Alters Social Interactive Traits But Not Open-field Behavior In Fischer 344 Rats

机译：产妇环境改变了Fischer 344大鼠的社交互动特征，但没有改变野外行为

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Although it is recognized that the genetic background governs behavioral phenotypes, environmental factors also play a critical role in the development of various behavioral processes. The maternal environment has a major impact on pups, and the cross-fostering procedure is used to determine the influence of early life experiences. The present study examined the influence of maternal environment on behavioral traits in inbred Fischer 344 (F344) rats. F344/DuCrlCrlj and Wistar (Crlj:WI) pups were fostered from postnatal day 1 as follows: Wistar pups raised by Wistar dams, F344 raised by Wistar, Wistar raised by F344, and F344 raised by F344. At 10 weeks of age, rats were randomly assigned to an open-field test and social interaction test. In the open-field test, irrespective of the rearing conditions, the activity during the first 1 min was significantly lower in F344 rats than in Wistar rats. Latency to the onset of movement showed no difference between groups. In the social interaction test, the recognition performance during the first 1 min in F344 raised by F344 was significantly shorter than that in the other groups. The onset of recognition to a novel social partner in F344 raised by F344 was significantly delayed, and the delay disappeared upon cross-fostering by Wistar dams. These results raise the possibility that the behavioral phenotype of F344 rats results from the interplay of genetic factors and maternal environment during early life, and that F344 rats are a strain with high susceptibility to rearing conditions for the formation of their emotionality.
机译：尽管已经认识到遗传背景决定着行为表型，但环境因素在各种行为过程的发展中也起着关键作用。产妇环境对幼崽有重大影响，并且采用交叉养育程序来确定早期生活经历的影响。本研究检查了母体环境对近交Fischer 344（F344）大鼠行为特征的影响。 F344 / DuCrlCrlj和Wistar（Crlj：WI）幼崽从出生后第1天开始按以下步骤饲养：Wistar水坝饲养的Wistar幼崽，Wistar饲养的F344，F344饲养的Wistar和F344饲养的F344。在10周大时，将大鼠随机分为一个开放视野测试和社交互动测试。在野外试验中，无论饲养条件如何，F344大鼠在最初1分钟内的活性均显着低于Wistar大鼠。运动开始的潜伏期显示两组之间没有差异。在社交互动测试中，由F344提高的F344在最初1分钟内的识别性能明显低于其他组。由F344引起的对F344中的新型社交伙伴的认可被大大延迟了，并且这种延迟在Wistar大坝进行交叉培育后消失了。这些结果增加了F344大鼠的行为表型是由早期生命中遗传因素和母体环境的相互作用产生的，并且F344大鼠是对饲养条件形成情绪的敏感性高的菌株。

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