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Forming two-dimensional structure of DNA-functionalized Au nanoparticles via lipid diffusion in supported lipid bilayers

机译:通过脂质扩散在支持的脂质双层中形成DNA功能化的Au纳米颗粒的二维结构

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摘要

Two-dimensional (2D) form of DNA-functionalized gold nanoparticles (DNA-AuNPs) has been studied. To confine the DNA-AuNPs in 2D space, we utilized the strong affinity between DNA molecules and supported lipid bilayers (SLBs). DNA-AuNPs adsorbed onto cationic SLB consisting of Dimethyl dioctadecyl ammonium bromide (DDAB) on mica substrate with high affinity. Owing to the high mobility of lipid molecules, 2D diffusion and transportation of DNA-AuNPs on the SLB was achieved. Using AFM imaging we confirmed a selective adsorption of DNA-AuNPs onto cationic lipid bilayer patches on mica surface, and then we confirmed a drastic formation change of DNA-AuNPs on the SLB with annealing. We observed that the DNA-AuNPs assembled into a densely-packed single-layered 2D superstructure through DNA hybridization.
机译:已经研究了DNA功能化的金纳米颗粒(DNA-AuNPs)的二维(2D)形式。为了将DNA-AuNPs限制在2D空间中,我们利用了DNA分子与支持的脂质双层(SLB)之间的强大亲和力。 DNA-AuNPs以高亲和力吸附在云母基质上的阳离子SLB上,该阳离子SLB由二甲基二十八烷基溴化铵(DDAB)组成。由于脂质分子的高迁移率,实现了DNA-AuNPs在SLB上的二维扩散和转运。使用原子力显微镜成像,我们确认了DNA-AuNPs在云母表面阳离子脂质双层膜上的选择性吸附,然后我们确认了退火后SLB上DNA-AuNPs的急剧形成变化。我们观察到,DNA-AuNPs通过DNA杂交组装成密集堆积的单层2D上部结构。

著录项

  • 来源
    《Journal of Crystal Growth》 |2014年第1期|494-498|共5页
  • 作者单位

    Department of Materials Science and Engineering, Nagoya University, Japan;

    Institut Lumiere Matiere, UMR5306 Universite Lyon 1-CNRS, France;

    Department of Materials Science and Engineering, Nagoya University, Japan;

    Department of Materials Science and Engineering, Nagoya University, Japan;

    The Electronics-Inspired Interdisciplinary Research Institute, Toyohashi University of Technology, Japan;

    Department of Materials Science and Engineering, Nagoya University, Japan;

    Department of Materials Science and Engineering, Nagoya University, Japan;

    Department of Materials Science and Engineering, Nagoya University, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    A1. Nanoparticle; A1. Self-assembly; A3. Superstructure; B1. DNA; B1. Lipid; B1. Supported lipid bilayer;

    机译:A1。纳米粒子A1。自组装;A3。上层建筑B1。脱氧核糖核酸;B1。脂质B1。支持的脂质双层;

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