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首页> 外文期刊>Journal of materials science >Temperature-sensitive star-shaped block copolymers hydrogels for an injection application: phase transition behavior and biocompatibility
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Temperature-sensitive star-shaped block copolymers hydrogels for an injection application: phase transition behavior and biocompatibility

机译：注射用温度敏感型星形嵌段共聚物水凝胶：相变行为和生物相容性

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摘要

A series of star-shaped poly(D,L-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (PLGA-mPEG) block copolymers with varying PLGA/mPEG block weight ratios, mPEG block length, and arm numbers were synthesized and phase transition behaviors were investigated. Phase transition characteristics, such as critical gel concentration (CGC) and critical gel temperature (CGT), were closely related to the molecular structure of the star-shaped block copolymers. The CGC was mainly determined by the balance of hydrophobic PLGA and hydrophilic mPEG block (PLGA/mPEG block ratio). The CGTs showed a stronger dependence on mPEG block length and arm number. Also, the CGTs can be adjusted by adding mPEG homopolymer additives. The weight fraction of mPEG had a stronger influence on the CGT values than molecular weight of mPEG. In addition, the MTT assay and histological observations confirmed the acceptable biocompatibility of the star-shaped block copolymer. Hence, the star-shaped PLGA-mPEG block copolymer was a promising candidate as a novel injectable gel.
机译：一系列具有不同PLGA / mPEG嵌段重量比，mPEG嵌段长度和臂的星形聚（D，L-乳酸-乙醇酸共聚物）-b-甲氧基聚（乙二醇）（PLGA-mPEG）嵌段共聚物合成了数并研究了相变行为。相转变特性，例如临界凝胶浓度（CGC）和临界凝胶温度（CGT），与星形嵌段共聚物的分子结构密切相关。 CGC主要由疏水PLGA和亲水性mPEG嵌段的平衡（PLGA / mPEG嵌段比率）确定。 CGT显示出对mPEG嵌段长度和臂数的更强依赖性。同样，可以通过添加mPEG均聚物添加剂来调节CGT。 mPEG的重量分数比cPEG的分子量对CGT值的影响更大。另外，MTT测定和组织学观察证实了星形嵌段共聚物的可接受的生物相容性。因此，星形PLGA-mPEG嵌段共聚物作为新型可注射凝胶是有希望的候选者。

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  • 来源
    《Journal of materials science》 |2013年第3期|689-700|共12页
  • 作者

    Lei Nie; Peng Zou; Shuibin Feng; Jinping Suo;

  • 作者单位

    State Key Laboratory of Mould Technology,College of Materials Science and Engineering,Huazhong University of Science and Technology (HUST),Wuhan 430074, People's Republic of China;

    State Key Laboratory of Mould Technology,College of Materials Science and Engineering,Huazhong University of Science and Technology (HUST),Wuhan 430074, People's Republic of China;

    State Key Laboratory of Mould Technology,College of Materials Science and Engineering,Huazhong University of Science and Technology (HUST),Wuhan 430074, People's Republic of China;

    State Key Laboratory of Mould Technology,College of Materials Science and Engineering,Huazhong University of Science and Technology (HUST),Wuhan 430074, People's Republic of China;

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