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首页> 外文期刊>Journal of Molecular Histology >Binding of Isolectin IB4 to Neurons of the Mouse Enteric Nervous System
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Binding of Isolectin IB4 to Neurons of the Mouse Enteric Nervous System

机译：Isolectin IB4与小鼠肠神经系统神经元的结合

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摘要

The plant lectin, IB4, binds to primary afferent neurons of dorsal root and trigeminal ganglia, where it is selective for nociceptive neurons. In the enteric nervous system of the guinea-pig IB4 labels intrinsic primary afferent neurons, which are believed to have roles as nociceptors. Here we investigate whether IB4 binding is also a marker of intrinsic primary afferent neurons in the mouse. Neurons that bound IB4 were common in the enteric plexuses of the small intestine and colon. Labeled neurons were rare in the stomach, and absent from the esophagus and gallbladder. Binding was to the cell surface, initial parts of axons and to clumps in the cytoplasm. Similar binding occurred on small and medium sized neurons of dorsal root, nodose and trigeminal ganglia. In the enteric nervous system, IB4 revealed large round or oval (type II) neurons, type I neurons with prominent laminar dendrites and small neurons of myenteric ganglia. The type II neurons were immunoreactive for calretinin, and some type I neurons were immunoreactive for nitric oxide synthase. Most neurons in the submucosal ganglia bound IB4, and some of these were vasoactive intestinal peptide immunoreactive. Thus IB4 binds to specific subgroups of enteric neurons in the mouse. These include intrinsic primary afferent neurons, but other neurons, including secretomotor neurons, are labeled. The results suggest that IB4 is not a specific label for enteric nociceptive neurons.
机译：植物凝集素IB4与背根和三叉神经节的初级传入神经元结合，对伤害性神经元具有选择性。在豚鼠的肠神经系统中，IB4标记固有的初级传入神经元，据信它们具有伤害感受器的作用。在这里，我们调查IB4结合是否也是小鼠内源性初级传入神经元的标记。结合IB4的神经元在小肠和结肠的肠丛中很常见。标记的神经元在胃中很少见，食道和胆囊中没有。结合到细胞表面，轴突的初始部分和细胞质中的团块。类似的结合发生在背根，结节和三叉神经节的中小型神经元上。在肠神经系统中，IB4表现出大的圆形或椭圆形（II型）神经元，具有突出的层状树突的I型神经元和肌小节的小神经元。 II型神经元对Calretinin具有免疫反应性，而某些I型神经元对一氧化氮合酶具有免疫反应性。粘膜下神经节中的大多数神经元结合IB4，其中一些是血管活性肠肽免疫反应性。因此，IB4与小鼠肠神经元的特定亚组结合。这些包括固有的初级传入神经元，但其他神经元（包括分泌运动神经元）也被标记。结果表明，IB4不是肠伤害感受性神经元的特异性标记。

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  • 来源
    《Journal of Molecular Histology》 |2006年第2期|61-68|共8页
  • 作者

    Michelle Thacker; Feng Lan Zhang; Sebastian R Jungnickel; John B Furness;

  • 作者单位

    Department of Anatomy ampamp Cell Biology and Centre for Neuroscience University of Melbourne Parkville Victoria 3010 Australia;

    Department of Anatomy ampamp Cell Biology and Centre for Neuroscience University of Melbourne Parkville Victoria 3010 Australia;

    Department of Anatomy ampamp Cell Biology and Centre for Neuroscience University of Melbourne Parkville Victoria 3010 Australia;

    Department of Anatomy ampamp Cell Biology and Centre for Neuroscience University of Melbourne Parkville Victoria 3010 Australia;

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  • 正文语种 eng
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  • 关键词

    Enteric nervous system; Lectin binding; Primary afferent neurons; Nociceptors;

    机译：肠神经系统;凝集素结合;初级传入神经元;伤害感受器;

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