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首页> 外文期刊>Journal of Polymers and the Environment >Characterization of Super Paramagnetic Nanoparticles Coated with a Biocompatible Polymer Produced by Dextransucrase from Weissella cibaria JAG8
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Characterization of Super Paramagnetic Nanoparticles Coated with a Biocompatible Polymer Produced by Dextransucrase from Weissella cibaria JAG8

机译：魏氏菌JAG8葡聚糖转葡糖酶生物相容性聚合物包覆的超顺磁性纳米粒子的表征

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摘要

Magnetic nanoparticles (MNPs) synthesised by chemical co-precipitation method was subjected to dextran coating by sonication method. The dextran was enzymatically synthesised by extracellular dextransucrase isolated from Weissella cibaria JAG8. The crystalline nature of MNPs and dextran coated MNPs were confirmed by X-ray diffraction studies with average particle size of 25 nm, which was confirmed further by high resolution transmission electron microscopy. The surface morphology of MNPs and dextran coated MNPs were monitored by scanning electron microscopy studies. The vibrating sample magnetometer investigation displayed the super paramagnetic nature of MNPs and dextran coated MNPs. FT-IR analysis of MNPs and dextran coated MNPs, displayed characteristic band of Fe-O bond at 582 cm(-1). Thermo-gravimetric analysis of MNPs and dextran coated MNPs (1:1) ratio displayed a weight loss of 15 and 18 %, which clearly indicated 3.0 % of dextran was coated on to the MNPs. The elemental composition study by scanning electron microscopy confirmed the association of dextran with MNPs. The in vitro effect of MNPs and dextran coated MNPs was performed on human colon cancer (HT-29) cell lines and the results showed that dextran coated: MNPs (2:1) displayed good biocompatibility results over dextran coated: MNPs (1:1) and un-coated MNPs.
机译：通过化学共沉淀法合成的磁性纳米颗粒（MNP）通过超声处理进行葡聚糖涂层。葡聚糖是通过从Weissella cibaria JAG8分离的细胞外葡聚糖酶酶促合成的。通过X射线衍射研究证实了MNP和葡聚糖包被的MNP的晶体性质，其平均粒径为25nm，这通过高分辨率透射电子显微镜进一步证实。通过扫描电子显微镜研究监测MNP和葡聚糖包被的MNP的表面形态。振动样品磁力计研究显示了MNP和葡聚糖包被的MNP的超顺磁性。 FT-IR分析MNPs和葡聚糖包被的MNPs，在582 cm（-1）处显示Fe-O键的特征带。 MNP和右旋糖酐涂覆的MNP（1：1）比率的热重分析显示重量减少了15％和18％，这清楚地表明3.0％的右旋糖酐被覆盖在MNP上。通过扫描电子显微镜对元素组成的研究证实了葡聚糖与MNP的关联。 MNPs和葡聚糖包被的MNPs对人结肠癌（HT-29）细胞系进行了体外作用，结果表明，葡聚糖包被的MNPs（2：1）优于葡聚糖包被的MNPs（1：1） ）和未镀膜的MNP。

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