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首页> 外文期刊>Mycotoxin Research >The production of aflatoxin B1 or G1 by Aspergillus parasiticus at various combinations of temperature and water activity is related to the ratio of aflS to aflR expression
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The production of aflatoxin B1 or G1 by Aspergillus parasiticus at various combinations of temperature and water activity is related to the ratio of aflS to aflR expression

机译：寄生曲霉在温度和水活性的各种组合下黄曲霉毒素B 1 或G 1 的产生与aflS与aflR表达的比率有关

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摘要

The influence of varying combinations of water activity (aw) and temperature on growth, aflatoxin biosynthesis and aflR/aflS expression of Aspergillus parasiticus was analysed in the ranges 17–42°C and 0.90–0.99 aw. Optimum growth was at 35°C. At each temperature studied, growth increased from 0.90 to 0.99 aw. Temperatures of 17 and 42°C only supported marginal growth. The external conditions had a differential effect on aflatoxin B1 or G1 biosynthesis. The temperature optima of aflatoxin B1 and G1 were not at the temperature which supported optimal growth (35°C) but either below (aflatoxin G1, 20–30°C) or above (aflatoxin B1, 37°C). Interestingly, the expression of the two regulatory genes aflR and aflS showed an expression profile which corresponded to the biosynthesis profile of either B1 (aflR) or G1 (aflS). The ratios of the expression data between aflS:aflR were calculated. High ratios at a range between 17 and 30°C corresponded with the production profile of aflatoxin G1 biosynthesis. A low ratio was observed at >30°C, which was related to aflatoxin B1 biosynthesis. The results revealed that the temperature was the key parameter for aflatoxin B1, whereas it was water activity for G1 biosynthesis. These differences in regulation may be attributed to variable conditions of the ecological niche in which these species occur.
机译：在17–42°C和0.90–0.99 a <范围内分析了水分活度（a w ）和温度的不同组合对寄生曲霉的生长，黄曲霉毒素生物合成和aflR / aflS表达的影响。 sub> w 。最佳生长温度为35°C。在每个研究温度下，生长量从0.90增加到0.99 a w 。 17和42°C的温度仅支持边际增长。外界条件对黄曲霉毒素B 1 或G 1 的生物合成有不同的影响。黄曲霉毒素B 1 和G 1 的最佳温度不是在支持最佳生长的温度（35°C）下，而是低于（黄曲霉毒素G 1 ，20–30°C）或更高（黄曲霉毒素B 1 ，37°C）。有趣的是，两个调节基因aflR和aflS的表达显示出与B 1 （aflR）或G 1 （aflS）的生物合成谱相对应的表达谱。计算表达数据在aflS：aflR之间的比率。在17至30°C范围内的高比例对应于黄曲霉毒素G 1 生物合成的产量特征。在> 30°C时观察到较低的比率，这与黄曲霉毒素B 1 的生物合成有关。结果表明，温度是黄曲霉毒素B 1 的关键参数，而水是G 1 生物合成的水分活度。这些调节上的差异可能归因于这些物种发生的生态位的可变条件。

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