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Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme

机译：隐秘的遗传变异促进RNA酶的快速进化适应

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摘要

Cryptic variation is caused by the robustness of phenotypes to mutations~1. Cryptic variation has no effect on phenotypes in a given genetic or environmental background, but it can have effects after mutations or environmental change~(2-5). Because evolutionary adaptation by natural selection requires phenotypic variation, phenotypically revealed cryptic genetic variation may facilitate evolutionary adaptation~(6-8). This is possible if the cryptic variation happens to be pre-adapted, or "exapted"~9, to a new environment, and is thus advantageous once revealed. However, this facilitating role for cryptic variation has not been proven, partly because most pertinent work focuses on complex phenotypes of whole organisms whose genetic basis is incompletely understood. Here we show that populations of RNA enzymes with accumulated cryptic variation adapt more rapidly to a new substrate than a population without cryptic variation. A detailed analysis of our evolving RNA populations in genotype space shows that cryptic variation allows a population to explore new genotypes that become adaptive only in a new environment. Our observations show that cryptic variation contains new genotypes pre-adapted to a changed environment. Our results highlight the positive role that robustness and epistasis can have in adaptive evolution~(10,11).
机译：表型对突变〜1的鲁棒性引起了密码学变异。在给定的遗传或环境背景下，隐性变异对表型没有影响，但是在突变或环境变化后，隐性变异才有影响〜（2-5）。由于通过自然选择进行进化适应需要表型变异，因此从表型上揭示的隐性遗传变异可能有助于进化适应[6-8]。如果秘密变化恰好是预先适应或“适应”到新环境的，则这是可能的，并且因此一旦被揭示是有利的。然而，尚未证明这种促成隐性变异的促进作用，部分原因是因为大多数相关工作都集中在遗传基础尚未完全理解的整个生物体的复杂表型上。在这里，我们显示了具有积累的隐蔽变异的RNA酶种群比没有隐蔽变异的种群更迅速地适应新的底物。对我们在基因型空间中不断发展的RNA种群的详细分析表明，隐性变异使种群能够探索仅在新环境中具有适应性的新基因型。我们的观察结果表明，隐秘变异包含预先适应变化的环境的新基因型。我们的研究结果突出了鲁棒性和上位性在适应性进化中的积极作用〜（10,11）。

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  • 来源
    《Nature》 |2011年第7349期|p.92-95|共4页
  • 作者

    Eric J. Hayden; Evandro Ferrada; Andreas Wagner;

  • 作者单位

    Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland,The Swiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, 1015 Lausanne,Switzerland;

    Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland,The Swiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, 1015 Lausanne,Switzerland;

    Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland,The Swiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, 1015 Lausanne,Switzerland,The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, New Mexico 87501, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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