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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma
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Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma

机译：低剂量金丝桃素-PDT在患有CT26结肠癌的BALB / c小鼠中诱导肿瘤完全消退

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Background: Successful tumor eradication with photodynamic therapy (PDT) in vivo depends on the optimal combination of treatment parameters. (Low-dose) PDT may additionally induce antitumoral immune responses. Since the naturally occurring hypericin (Hyp) is a promising pho-tosensitizer for PDT, the aim of the study was to investigate phototoxic and immunologic effects of a low-dose Hyp-PDT on murine tumors in contrast to commonly used Hyp-PDT conditions. Methods: BALB/c mice bearing CT26 colon carcinoma received hypericin intravenously and were irradiated with red light 0.5-4 h later. Tumor development was recorded. Mice were then re-challenged 60 days after the first tumor cell inoculation to investigate an antitumoral immune response. Results: Different results of tumor/host responses were obtained, ranging from mice exitus over delayed tumor growth to complete tumor regression according to different treatment protocols. PDT with common doses and a 4h drug—light-interval resulted in a four times delayed tumor growth compared to the control groups. PDT with relatively low doses and a drug-light-interval of 0.5 h led to 100% tumor eradication. Re-challenge of these mice with CT26 mouse colon carcinoma cells prevented new tumor growth. Conclusions: Not only drug concentrations and light doses seem to determine the efficiency of tumor eradication, but also the localization of hypericin at the time of irradiation. Targets in our low-dose PDT protocol are exclusively the vessels. The advantage of this low-dose PDT beside less drug and light exposure of the animals is reduced skin damage, faster healing of the lesions and induction of an antitumoral immune response.
机译：背景：在体内通过光动力疗法（PDT）成功根除肿瘤取决于治疗参数的最佳组合。 （低剂量）PDT可能另外诱导抗肿瘤免疫反应。由于天然的金丝桃素（Hyp）是一种有前途的PDT光敏剂，因此该研究的目的是研究低剂量Hyp-PDT与常用的Hyp-PDT条件相比对小鼠肿瘤的光毒性和免疫学作用。方法：携带CT26结肠癌的BALB / c小鼠静脉注射金丝桃素，并在0.5-4 h后用红光照射。记录肿瘤的发展。然后在第一次肿瘤细胞接种后60天再次攻击小鼠以研究抗肿瘤免疫反应。结果：获得了不同的肿瘤/宿主反应结果，范围从因肿瘤生长延迟而退出的小鼠退出，直至根据不同的治疗方案完成肿瘤消退。与对照组相比，常规剂量的PDT和4小时的药物间隔时间导致肿瘤生长延迟了四倍。相对低剂量的PDT和0.5 h的药物光照间隔可100％根除肿瘤。用CT26小鼠结肠癌细胞对这些小鼠进行再攻击可防止新的肿瘤生长。结论：不仅药物浓度和光剂量似乎决定了根除肿瘤的效率，而且还决定了金丝桃素在照射时的定位。低剂量PDT协议中的目标仅是血管。这种低剂量PDT的优点是减少了动物对药物的暴露和暴露，减少了皮肤损害，加快了病灶的愈合速度，并诱导了抗肿瘤免疫反应。

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