Isolated guanine quadruplex structures have been described at high resolution both in solution and in the solid state. The existence of this unusual DNA structure in vivo and its biological significance remain to be determined. We describe the binding of 3,3'-diethyloxadicarbocyanine to dimeric hairpin guanine quadruplexes. This interaction re- sults in a set of unique spectrophotometric signatures, none of which arises from binding to single strands or Watson- Crick duplexes.
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